Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Ectopic Expression of X-Linked Lymphocyte-Regulated Protein pM1 Renders Tumor Cells Resistant to Antitumor Immunity

Authors
Kang, Tae HeungNoh, Kyung HeeKim, Jin HeeBae, Hyun CheolLin, Ken Y.Monie, ArchanaPai, Sara I.Hung, Chien-FuWu, T. -C.Kim, Tae Woo
Issue Date
15-4월-2010
Publisher
AMER ASSOC CANCER RESEARCH
Keywords
Cancer; CTL; apoptosis; immune resistance; XLR; SCP3
Citation
CANCER RESEARCH, v.70, no.8, pp.3062 - 3070
Indexed
SCIE
SCOPUS
Journal Title
CANCER RESEARCH
Volume
70
Number
8
Start Page
3062
End Page
3070
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/116628
DOI
10.1158/0008-5472.CAN-09-3856
ISSN
0008-5472
Abstract
Tumor immune escape is a major obstacle in cancer immunotherapy, but the mechanisms involved remain poorly understood. We have previously developed an immune evasion tumor model using an in vivo immune selection strategy and revealed Akt-mediated immune resistance to antitumor immunity induced by various cancer immunotherapeutic agents. In the current study, we used microarray gene analysis to identify an Akt-activating candidate molecule overexpressed in immune-resistant tumors compared with parental tumors. X-linked lymphocyte-regulated protein pM1 (XLR) gene was the most upregulated in immune-resistant tumors compared with parental tumor cells. Furthermore, the retroviral transduction of XLR in parental tumor cells led to activation of Akt, resulting in upregulation of antiapoptotic proteins and the induction of immune resistance phenotype in parental tumor cells. In addition, we found that transduction of parental tumor cells with other homologous genes from the mouse XLR family, such as synaptonemal complex protein 3 (SCP3) and XLR-related, meiosis-regulated protein (XMR) and its human counterpart of SCP3 (hSCP3), also led to activation of Akt, resulting in the upregulation of antiapoptotic proteins and induction of immune resistance phenotype. Importantly, characterization of a panel of human cervical cancers revealed relatively higher expression levels of hSCP3 in human cervical cancer tissue compared with normal cervical tissue. Thus, our data indicate that ectopic expression of XLR and its homologues in tumor cells represents a potentially important mechanism for tumor immune evasion and serves as a promising molecular target for cancer immunotherapy. Cancer Res; 70(8); 3062-70. (C) 2010 AACR.
Files in This Item
There are no files associated with this item.
Appears in
Collections
Graduate School > Department of Biomedical Sciences > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE