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Assessment of penetration of quantum dots through in vitro and in vivo human skin using the human skin equivalent model and the tape stripping method
- Authors
- Jeong, Sang Hoon; Kim, Jae Hwan; Yi, Sang Min; Lee, Jung Pyo; Kim, Jin Ho; Sohn, Kyung Hee; Park, Kui Lea; Kim, Meyoung-Kon; Son, Sang Wook
- Issue Date
- 9-4월-2010
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- Quantum dots; Stratum corneum; Human skin equivalent model; Tape stripping method; Skin penetration
- Citation
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.394, no.3, pp.612 - 615
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Volume
- 394
- Number
- 3
- Start Page
- 612
- End Page
- 615
- ISSN
- 0006-291X
- Abstract
- Quantum clots (QDs) are rapidly emerging as an important class of nanoparticles (NPs) with potential applications in medicine However, little is known about penetration of QDs through human skin This study investigated skin penetration of QDs in both in vivo and in vitro human skin Using the tape stripping method, this study demonstrates for the first time that QDs can actually penetrate through the stratum corneum (SC) of human skin Transmission electron microscope (TEM) and energy diverse X-ray (EDX) analysis showed accumulation of QDs in the SC of a human skin equivalent model (HSEM) after dermal exposure to QDs These findings suggest possible transdermal absorption of QDs after dermal exposure over a relatively long period of time (C) 2010 Elsevier Inc All rights reserved
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