MRP1 Polymorphisms Associated With Citalopram Response in Patients With Major Depression
DC Field | Value | Language |
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dc.contributor.author | Lee, Sung Hee | - |
dc.contributor.author | Lee, Min-Soo | - |
dc.contributor.author | Lee, Ji Hyun | - |
dc.contributor.author | Kim, So Won | - |
dc.contributor.author | Kang, Rhee-Hun | - |
dc.contributor.author | Choi, Myoung-Jin | - |
dc.contributor.author | Park, Sang Jin | - |
dc.contributor.author | Kim, Se Joo | - |
dc.contributor.author | Lee, Jae Myun | - |
dc.contributor.author | Cole, Susan P. C. | - |
dc.contributor.author | Lee, Min Goo | - |
dc.date.accessioned | 2021-09-08T04:01:24Z | - |
dc.date.available | 2021-09-08T04:01:24Z | - |
dc.date.created | 2021-06-11 | - |
dc.date.issued | 2010-04 | - |
dc.identifier.issn | 0271-0749 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/116664 | - |
dc.description.abstract | Multidrug resistance protein 1 (MRP1, ABCC1) transports antidepressive agents in the endothelial cells of the blood-brain barrier. Therefore, polymorphisms in the MRP1 gene may affect the treatment response of antidepressants. This study was aimed to identify the association between genetic variations in MRP1/ABCC1 and the therapeutic response to the antidepressant citalopram. One hundred and twenty-three patients who had been treated with citalopram monotherapy to control their major depressive disorder were recruited, and genotype data from 64 patients who had completed their 8-week follow-up were evaluated together with those from 100 controls. Nine MRP1 single nucleotide polymorphisms (SNPs) showing more than 5% allele frequency in the Korean population were analyzed. The c.4002G>A, a synonymous SNP in exon 28, showed a strong association with the remission state at 8 weeks (P = 0.005, odds ratio [OR], 4.7, 95% confidence interval [CI], 1.5 similar to 14.7). The c.4002G>A forms a linkage disequilibrium block with 3 other SNPs including c.5462T>A in the 3' untranslated region. Accordingly, the haplotype showed a significant association with the remission state (P = 0.014). Subsequent molecular studies also supported the association between these MRP1 polymorphisms and the citalopram response. Thus, kinetic studies using MRP1-enriched membrane vesicles revealed that citalopram is a substrate of MRP1 (K-m = 1.99 mu M, V-max = 137 pmol/min per milligram protein). In addition, individuals with c. 4002G>A or c. 5462T>A polymorphisms showed higher MRP1 mRNA levels in peripheral blood cells. These results suggest that MRP1 polymorphisms may be a predictive marker of citalopram treatment in major depression. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject | MULTIDRUG-RESISTANCE PROTEIN | - |
dc.subject | STAR-ASTERISK-D | - |
dc.subject | TRANSPORTER GENE | - |
dc.subject | P-GLYCOPROTEIN | - |
dc.subject | DRUG TRANSPORTERS | - |
dc.subject | CLINICAL-RESPONSE | - |
dc.subject | BRAIN | - |
dc.subject | ABCC1 | - |
dc.subject | MICRORNA | - |
dc.subject | ANTIDEPRESSANTS | - |
dc.title | MRP1 Polymorphisms Associated With Citalopram Response in Patients With Major Depression | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Min-Soo | - |
dc.identifier.doi | 10.1097/JCP.0b013e3181d2ef42 | - |
dc.identifier.scopusid | 2-s2.0-77952162644 | - |
dc.identifier.wosid | 000275722300004 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, v.30, no.2, pp.116 - 125 | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY | - |
dc.citation.title | JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY | - |
dc.citation.volume | 30 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 116 | - |
dc.citation.endPage | 125 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.subject.keywordPlus | MULTIDRUG-RESISTANCE PROTEIN | - |
dc.subject.keywordPlus | STAR-ASTERISK-D | - |
dc.subject.keywordPlus | TRANSPORTER GENE | - |
dc.subject.keywordPlus | P-GLYCOPROTEIN | - |
dc.subject.keywordPlus | DRUG TRANSPORTERS | - |
dc.subject.keywordPlus | CLINICAL-RESPONSE | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | ABCC1 | - |
dc.subject.keywordPlus | MICRORNA | - |
dc.subject.keywordPlus | ANTIDEPRESSANTS | - |
dc.subject.keywordAuthor | MRP1/ABCC1 | - |
dc.subject.keywordAuthor | citalopram | - |
dc.subject.keywordAuthor | remission | - |
dc.subject.keywordAuthor | major depressive disorder | - |
dc.subject.keywordAuthor | ABC transporter | - |
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