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Pathological roles of MAPK signaling pathways in human diseases

Authors
Kim, Eun KyungChoi, Eui-Ju
Issue Date
4월-2010
Publisher
ELSEVIER SCIENCE BV
Keywords
MAPK; JNK; p38; Neurodegenerative disease; Cancer
Citation
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, v.1802, no.4, pp.396 - 405
Indexed
SCIE
SCOPUS
Journal Title
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
Volume
1802
Number
4
Start Page
396
End Page
405
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/116675
DOI
10.1016/j.bbadis.2009.12.009
ISSN
0925-4439
Abstract
The mammalian family of mitogen-activated protein kinases (MAPKs) includes extracellular signal-regulated kinase (ERK), p38, and c-Jun NH2-terminal kinase (JNK), with each MAPK signaling pathway consisting of at least three components, a MAPK kinase kinase (MAP3K), a MAPK kinase (MAP2K), and a MAPK. The MAPK pathways are activated by diverse extracellular and intracellular stimuli including peptide growth factors, cytokines, hormones, and various cellular stressors such as oxidative stress and endoplasmic reticulum stress. These signaling pathways regulate a variety of cellular activities including proliferation, differentiation, survival, and death. Deviation from the strict control of MAPK signaling pathways has been implicated in the development of many human diseases including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and various types of cancers. Persistent activation of the JNK or p38 signaling pathways has been suggested to mediate neuronal apoptosis in AD, PD, and ALS, whereas the ERK signaling pathway plays a key role in several steps of tumorigenesis including cancer cell proliferation, migration, and invasion. In this review, we summarize recent findings on the roles of MAPK signaling pathways in human disorders, focusing on cancer and neurodegenerative diseases including AD, PD, and ALS. (C) 2010 Elsevier B.V. All rights reserved.
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