Pro-survival of estrogen receptor-negative breast cancer cells is regulated by a BLT2-reactive oxygen species-linked signaling pathway
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Jung-A | - |
dc.contributor.author | Lee, Jin-Wook | - |
dc.contributor.author | Kim, Hyunju | - |
dc.contributor.author | Kim, Eun-Young | - |
dc.contributor.author | Seo, Ji-Min | - |
dc.contributor.author | Ko, Jesang | - |
dc.contributor.author | Kim, Jae-Hong | - |
dc.date.accessioned | 2021-09-08T04:04:37Z | - |
dc.date.available | 2021-09-08T04:04:37Z | - |
dc.date.created | 2021-06-11 | - |
dc.date.issued | 2010-04 | - |
dc.identifier.issn | 0143-3334 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/116681 | - |
dc.description.abstract | Leukotriene B-4 (LTB4) is an inflammatory mediator with potent biological activities in the pathogenesis of many inflammatory diseases. In the present study, we found that expression of BLT2, a low-affinity LTB4 receptor, is significantly upregulated in breast cancer cells. In addition, we observed that inhibition of BLT2 by a specific antagonist, LY255283, or by siBLT2 RNA interference caused dramatic apoptotic cell death in breast cancer cells, especially in the estrogen receptor (ER)-negative MDA-MB-468 and MDA-MB-453 cells, suggesting a role for BLT2 in survival of these breast cancer cells. In an approach to understand the downstream mechanism by which BLT2 mediates the potential pro-survival signaling, we found that the elevated reactive oxygen species (ROS) generation is associated with BLT2-mediated survival. Expression of Nox1, a member of the NADPH oxidase family, is also highly upregulated in a BLT2-dependent manner in these breast cancer cells, suggesting that 'Nox1-derived ROS' lie downstream of BLT2. Consistent with the proposed role of 'Nox1-ROS' in pro-survival signaling, knockdown of Nox1 with siNox1 or treatment with a ROS scavenging agent caused dramatic apoptotic death in these breast cancer cells. Taken together, our results demonstrate, for the first time, that the 'BLT2-Nox1-ROS'-linked cascade is involved in the pro-survival signaling, especially in ER-negative breast cancer cells. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.subject | LEUKOTRIENE B-4 RECEPTOR | - |
dc.subject | C-MYC | - |
dc.subject | EXPRESSION | - |
dc.subject | APOPTOSIS | - |
dc.subject | TARGET | - |
dc.subject | OVEREXPRESSION | - |
dc.subject | PROLIFERATION | - |
dc.subject | NEUTROPHILS | - |
dc.subject | ACTIVATE | - |
dc.subject | CASCADE | - |
dc.title | Pro-survival of estrogen receptor-negative breast cancer cells is regulated by a BLT2-reactive oxygen species-linked signaling pathway | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ko, Jesang | - |
dc.contributor.affiliatedAuthor | Kim, Jae-Hong | - |
dc.identifier.doi | 10.1093/carcin/bgp203 | - |
dc.identifier.scopusid | 2-s2.0-77950878441 | - |
dc.identifier.wosid | 000276285200002 | - |
dc.identifier.bibliographicCitation | CARCINOGENESIS, v.31, no.4, pp.543 - 551 | - |
dc.relation.isPartOf | CARCINOGENESIS | - |
dc.citation.title | CARCINOGENESIS | - |
dc.citation.volume | 31 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 543 | - |
dc.citation.endPage | 551 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | LEUKOTRIENE B-4 RECEPTOR | - |
dc.subject.keywordPlus | C-MYC | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | TARGET | - |
dc.subject.keywordPlus | OVEREXPRESSION | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | NEUTROPHILS | - |
dc.subject.keywordPlus | ACTIVATE | - |
dc.subject.keywordPlus | CASCADE | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.