CK beta 8/CCL23 and its isoform CK beta 8-1 induce up-regulation of cyclins via the G(i)/G(o) protein/PLC/PKC delta/ERK leading to cell-cycle progression
DC Field | Value | Language |
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dc.contributor.author | Kim, Jeonghan | - |
dc.contributor.author | Kim, Yoon Suk | - |
dc.contributor.author | Ko, Jesang | - |
dc.date.accessioned | 2021-09-08T04:05:49Z | - |
dc.date.available | 2021-09-08T04:05:49Z | - |
dc.date.created | 2021-06-11 | - |
dc.date.issued | 2010-04 | - |
dc.identifier.issn | 1043-4666 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/116687 | - |
dc.description.abstract | CK beta 8/CCL23 is a CC chemokine and alternative splicing of the CK beta 8 gene produces two mRNAs that encode CK beta 8 and its isoform CK beta 8-1. Chemokines play a critical role in leukocyte trafficking and development of inflammation and chemokines are also known to be involved in cell proliferation. To investigate participation of CK beta 8 and CK beta 8-1 in cell proliferation, we examined the effects of CK beta 8 and CK beta 8-1 in the cell cycle. Both CK beta 8 and CK beta 8-1 induced cell-cycle progression. We next investigated whether MAPKs are involved in CK beta 8- and CK beta 8-1-induced cell proliferation. CK beta 8- and CK beta 8-1-stimulated cells showed phosphorylation of ERK1/2 and an inhibitor study indicated that CK beta 8- and CK beta 8-1-induced activation of ERK1/2 is mediated by the G(i)/G(o) protein, PLC, and PKC delta. CK beta 8 and CK beta 8-1 regulated expression of the cell cycle regulators cyclin D-3 and cyclin B-1, and the immediate early response gene products c-Myc and Egr-1. These results indicate that both CK beta 8 and CK beta 8-1 are involved in cell proliferation by modulating the cell cycle regulators. (C) 2009 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | - |
dc.subject | CHEMOKINE RECEPTORS | - |
dc.subject | CC-CHEMOKINE | - |
dc.subject | PROLIFERATION | - |
dc.subject | INHIBITORS | - |
dc.subject | SPECIFICITY | - |
dc.title | CK beta 8/CCL23 and its isoform CK beta 8-1 induce up-regulation of cyclins via the G(i)/G(o) protein/PLC/PKC delta/ERK leading to cell-cycle progression | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ko, Jesang | - |
dc.identifier.doi | 10.1016/j.cyto.2009.12.010 | - |
dc.identifier.scopusid | 2-s2.0-77049085215 | - |
dc.identifier.wosid | 000275986100007 | - |
dc.identifier.bibliographicCitation | CYTOKINE, v.50, no.1, pp.42 - 49 | - |
dc.relation.isPartOf | CYTOKINE | - |
dc.citation.title | CYTOKINE | - |
dc.citation.volume | 50 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 42 | - |
dc.citation.endPage | 49 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | CHEMOKINE RECEPTORS | - |
dc.subject.keywordPlus | CC-CHEMOKINE | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | INHIBITORS | - |
dc.subject.keywordPlus | SPECIFICITY | - |
dc.subject.keywordAuthor | CK beta 8 | - |
dc.subject.keywordAuthor | CK beta 8-1 | - |
dc.subject.keywordAuthor | Cell cycle | - |
dc.subject.keywordAuthor | Cyclin | - |
dc.subject.keywordAuthor | Signal transduction | - |
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