Predictive Value of Albuminuria in American Indian Youth With or Without Type 2 Diabetes
DC Field | Value | Language |
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dc.contributor.author | Kim, Nan Hee | - |
dc.contributor.author | Pavkov, Meda E. | - |
dc.contributor.author | Knowler, William C. | - |
dc.contributor.author | Hanson, Robert L. | - |
dc.contributor.author | Weil, E. Jennifer | - |
dc.contributor.author | Curtis, Jeffrey M. | - |
dc.contributor.author | Bennett, Peter H. | - |
dc.contributor.author | Nelson, Robert G. | - |
dc.date.accessioned | 2021-09-08T04:12:00Z | - |
dc.date.available | 2021-09-08T04:12:00Z | - |
dc.date.created | 2021-06-11 | - |
dc.date.issued | 2010-04 | - |
dc.identifier.issn | 0031-4005 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/116721 | - |
dc.description.abstract | OBJECTIVE: To examine the prognostic significance of elevated albuminuria in youth with type 2 diabetes. PATIENTS AND METHODS: Cross-sectional and prospective studies were conducted on Pima Indian youth aged 5 to 19 years at baseline who were examined between July 1, 1982, and December 31, 2007. Prevalence and sequential changes in the level of microalbuminuria (30 <= albumin-to-creatinine ratio [ACR] < 300 mg/g) and macroalbuminuria (ACR >= 300 mg/g) and incidence of macroalbuminuria were computed according to the presence or absence of type 2 diabetes. RESULTS: The prevalence of microalbuminuria and macroalbuminuria was 6.5% and 0.6% in the 3856 nondiabetic youth and 18.5% and 2.9% in the 103 youth with diabetes, respectively. One hundred forty-one of 187 (75.4%) nondiabetic youth, but only 1 of 14 (7.1%) diabetic youth with an elevated ACR (>= 30 mg/g) regressed to an undetectable or normal ACR (<30 mg/g) on subsequent examination. In a subset of 2666 youth with a median follow-up of 8.1 years, 36 nondiabetic and 30 diabetic youth with baseline ACRs of <300 mg/g developed macroalbuminuria. For a given ACR, the incidence of macroalbuminuria was 15.9-fold (95% confidence interval: 11.1-22.6) higher in the diabetic than in the nondiabetic youth. CONCLUSIONS: Elevated albuminuria is infrequent and largely transient in nondiabetic youth, but it is relatively frequent and largely persistent in those with diabetes. Microalbuminuria in youth with type 2 diabetes strongly predicts progression to macroalbuminuria, which supports annual screening for albuminuria. Pediatrics 2010; 125: e844-e851 | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER ACAD PEDIATRICS | - |
dc.subject | GLOMERULAR-FILTRATION-RATE | - |
dc.subject | PIMA-INDIANS | - |
dc.subject | GLUCOSE-TOLERANCE | - |
dc.subject | RENAL-DISEASE | - |
dc.subject | MICROALBUMINURIA | - |
dc.subject | PREVALENCE | - |
dc.subject | NEPHROPATHY | - |
dc.subject | EXCRETION | - |
dc.subject | MELLITUS | - |
dc.subject | YOUNG | - |
dc.title | Predictive Value of Albuminuria in American Indian Youth With or Without Type 2 Diabetes | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Nan Hee | - |
dc.identifier.doi | 10.1542/peds.2009-1230 | - |
dc.identifier.scopusid | 2-s2.0-77950565343 | - |
dc.identifier.wosid | 000276239600053 | - |
dc.identifier.bibliographicCitation | PEDIATRICS, v.125, no.4, pp.E844 - E851 | - |
dc.relation.isPartOf | PEDIATRICS | - |
dc.citation.title | PEDIATRICS | - |
dc.citation.volume | 125 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | E844 | - |
dc.citation.endPage | E851 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pediatrics | - |
dc.relation.journalWebOfScienceCategory | Pediatrics | - |
dc.subject.keywordPlus | GLOMERULAR-FILTRATION-RATE | - |
dc.subject.keywordPlus | PIMA-INDIANS | - |
dc.subject.keywordPlus | GLUCOSE-TOLERANCE | - |
dc.subject.keywordPlus | RENAL-DISEASE | - |
dc.subject.keywordPlus | MICROALBUMINURIA | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | NEPHROPATHY | - |
dc.subject.keywordPlus | EXCRETION | - |
dc.subject.keywordPlus | MELLITUS | - |
dc.subject.keywordPlus | YOUNG | - |
dc.subject.keywordAuthor | diabetic nephropathy | - |
dc.subject.keywordAuthor | epidemiology | - |
dc.subject.keywordAuthor | incidence | - |
dc.subject.keywordAuthor | longitudinal | - |
dc.subject.keywordAuthor | prevalence | - |
dc.subject.keywordAuthor | risk factors | - |
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