Associations Between Tumor Necrosis Factor-alpha (TNF-alpha)-308 and-238 G/A Polymorphisms and Shared Epitope Status and Responsiveness to TNF-alpha Blockers in Rheumatoid Arthritis: A Metaanalysis Update
DC Field | Value | Language |
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dc.contributor.author | Lee, Young Ho | - |
dc.contributor.author | Ji, Jong Dae | - |
dc.contributor.author | Bae, Sang-Cheol | - |
dc.contributor.author | Song, Gwan Gyu | - |
dc.date.accessioned | 2021-09-08T04:15:32Z | - |
dc.date.available | 2021-09-08T04:15:32Z | - |
dc.date.created | 2021-06-11 | - |
dc.date.issued | 2010-04 | - |
dc.identifier.issn | 0315-162X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/116740 | - |
dc.description.abstract | Objective. To investigate whether tumor necrosis factor-alpha (TNF-alpha) promoter -308 A/G and -238 A/G polymorphisms and shared epitope (SE) status are associated with responsiveness to anti-TNF therapy in patients with rheumatoid arthritis (RA). Methods. A comparative metaanalysis was conducted on A allele carriers (genotypes A/A + A/G) of the TNF-alpha promoter -308 and -238 A/C polymorphisms and SE status in responders and nonresponders to anti-TNF therapy. Results. A total of 13 studies were included in the metaanalysis. Metaanalysis showed that the TNF-alpha -308 A/G polymorphism is not associated with responsiveness to TNF blockers in RA patients. Studies with a small number of subjects (< 100) showed that the odds ratio for the A allele carrier state was significantly lower among responders (OR 0.344, 95% CI 0.152-0.779, p = 0.01). Studies with a higher number of subjects (>= 100) found no association between the TNF-alpha +308 A/C polymorphism and responsiveness to TNF blockers. The overall metaanalysis showed that the TNF-alpha -238 A/C polymorphism was not associated with the responsiveness of RA patients to TNF blockers, and stratification by TNF blocker revealed that the TNF-alpha 238 A/G polymorphism was associated with response of infliximab (OR 0.441, 95% CI 0.203-0.609, p = 0.039). SE status was found not to be associated with response to TNF blockers. Conclusion. Metaanalysis of available data revealed an association between treatment response to infliximab and the TNF-alpha -238 A/C polymorphism, but no associations between treatment response and the TNF-alpha -308 A/G polymorphism or SE status. (First Release March 1 2010; J Rheumatol 2010;37:740-6; doi:10.3899/jrheum.090707) | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | J RHEUMATOL PUBL CO | - |
dc.subject | PROMOTER POLYMORPHISM | - |
dc.subject | DIFFERENTIAL RESPONSE | - |
dc.subject | CLINICAL-RESPONSE | - |
dc.subject | THERAPY | - |
dc.subject | GENE | - |
dc.subject | INFLIXIMAB | - |
dc.subject | ETANERCEPT | - |
dc.subject | ADALIMUMAB | - |
dc.subject | POSITION-308 | - |
dc.subject | MECHANISMS | - |
dc.title | Associations Between Tumor Necrosis Factor-alpha (TNF-alpha)-308 and-238 G/A Polymorphisms and Shared Epitope Status and Responsiveness to TNF-alpha Blockers in Rheumatoid Arthritis: A Metaanalysis Update | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.identifier.doi | 10.3899/jrheum.090707 | - |
dc.identifier.scopusid | 2-s2.0-77950632641 | - |
dc.identifier.wosid | 000276783900010 | - |
dc.identifier.bibliographicCitation | JOURNAL OF RHEUMATOLOGY, v.37, no.4, pp.740 - 746 | - |
dc.relation.isPartOf | JOURNAL OF RHEUMATOLOGY | - |
dc.citation.title | JOURNAL OF RHEUMATOLOGY | - |
dc.citation.volume | 37 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 740 | - |
dc.citation.endPage | 746 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | PROMOTER POLYMORPHISM | - |
dc.subject.keywordPlus | DIFFERENTIAL RESPONSE | - |
dc.subject.keywordPlus | CLINICAL-RESPONSE | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | INFLIXIMAB | - |
dc.subject.keywordPlus | ETANERCEPT | - |
dc.subject.keywordPlus | ADALIMUMAB | - |
dc.subject.keywordPlus | POSITION-308 | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordAuthor | RHEUMATOID ARTHRITIS | - |
dc.subject.keywordAuthor | TUMOR NECROSIS FACTOR-alpha INHIBITORS | - |
dc.subject.keywordAuthor | TUMOR NECROSIS FACTOR-alpha POLYMORPHISM | - |
dc.subject.keywordAuthor | RESPONSIVENESS | - |
dc.subject.keywordAuthor | SHARED EPITOPE | - |
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