Protective Role of COMP-Ang1 in Ischemic Rat Brain
DC Field | Value | Language |
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dc.contributor.author | Shin, Hye Young | - |
dc.contributor.author | Lee, Yoon Jin | - |
dc.contributor.author | Kim, Hak Joo | - |
dc.contributor.author | Park, Chul-Kee | - |
dc.contributor.author | Kim, Jong Hoon | - |
dc.contributor.author | Wang, Kyu Chang | - |
dc.contributor.author | Kim, Dong Gyu | - |
dc.contributor.author | Koh, Gou Young | - |
dc.contributor.author | Paek, Sun Ha | - |
dc.date.accessioned | 2021-09-08T04:16:02Z | - |
dc.date.available | 2021-09-08T04:16:02Z | - |
dc.date.created | 2021-06-11 | - |
dc.date.issued | 2010-04 | - |
dc.identifier.issn | 0360-4012 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/116743 | - |
dc.description.abstract | In cerebral ischemia, the induction of angiogenesis may represent a natural defense mechanism that enables the hypoxic brain to avoid progression into infarction. Angiopoietin-1 (Ang1) is known to produce non-leaky and stable blood vessel formation mainly by the Tie2 receptor. Therefore, we envisioned that the application of cartilage oligomeric matrix protein-Ang1 (COMP-Ang1), a soluble, stable, and potent form of Ang1, would promote angiogenesis and provide a protective effect following unilateral middle cerebral artery occlusion (MCAO) in rats. To this end, we employed a 2-hour-MCAO model, and treated rats with adenovirus encoding COMP-Ang1 (Ade-COMP-Ang1) or control virus encoding beta-gal (Ade-beta-gal). Time course magnetic resonance images (MRIs) revealed significantly reduced infarct volume in the rats treated with Ade-COMP-Ang1 with an improvement of post-ischemic neurological deficits compared with rats treated with Ade-beta-gal. Moreover, compared to the rats treated with Ade-beta-gal, the rats treated with Ade-COMP-Ang1 showed an increase in blood vessels, especially in the border zone adjacent to the infarction, increased number of endogenous neuronal progenitor cells in the ischemic brain, and decreased number of TUNEL-positive cells. Taken together, COMP-Ang1 reduced infarct volume and consequently attenuated post-ischemic neurological deficits through enhanced angiogenesis and increased viable cell mass of neuronal cells. (C) 2009 Wiley-Liss, Inc. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject | DESIGNED ANGIOPOIETIN-1 VARIANT | - |
dc.subject | TISSUE-PLASMINOGEN ACTIVATOR | - |
dc.subject | CEREBRAL-ISCHEMIA | - |
dc.subject | BLOOD-FLOW | - |
dc.subject | STROKE | - |
dc.subject | ANGIOGENESIS | - |
dc.subject | MODEL | - |
dc.subject | EXPRESSION | - |
dc.subject | LEAKAGE | - |
dc.title | Protective Role of COMP-Ang1 in Ischemic Rat Brain | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jong Hoon | - |
dc.identifier.doi | 10.1002/jnr.22274 | - |
dc.identifier.scopusid | 2-s2.0-77950111925 | - |
dc.identifier.wosid | 000275583200013 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEUROSCIENCE RESEARCH, v.88, no.5, pp.1052 - 1063 | - |
dc.relation.isPartOf | JOURNAL OF NEUROSCIENCE RESEARCH | - |
dc.citation.title | JOURNAL OF NEUROSCIENCE RESEARCH | - |
dc.citation.volume | 88 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1052 | - |
dc.citation.endPage | 1063 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | DESIGNED ANGIOPOIETIN-1 VARIANT | - |
dc.subject.keywordPlus | TISSUE-PLASMINOGEN ACTIVATOR | - |
dc.subject.keywordPlus | CEREBRAL-ISCHEMIA | - |
dc.subject.keywordPlus | BLOOD-FLOW | - |
dc.subject.keywordPlus | STROKE | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | LEAKAGE | - |
dc.subject.keywordAuthor | Blood vessels | - |
dc.subject.keywordAuthor | cerebral ischemia | - |
dc.subject.keywordAuthor | Gene transfer | - |
dc.subject.keywordAuthor | Neuroprotection | - |
dc.subject.keywordAuthor | ischaemia | - |
dc.subject.keywordAuthor | Neurogenesis | - |
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