Responses to inhaled long-acting beta-agonist and corticosteroid according to COPD subtype
DC Field | Value | Language |
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dc.contributor.author | Lee, Ji-Hyun | - |
dc.contributor.author | Lee, Young Kyung | - |
dc.contributor.author | Kim, Eun-Kyung | - |
dc.contributor.author | Kim, Tae-Hyung | - |
dc.contributor.author | Huh, Jin Won | - |
dc.contributor.author | Kim, Woo Jin | - |
dc.contributor.author | Lee, Jin Hwa | - |
dc.contributor.author | Lee, Sang-Min | - |
dc.contributor.author | Lee, Sangyeub | - |
dc.contributor.author | Lim, Seong Yong | - |
dc.contributor.author | Shin, Tae Rim | - |
dc.contributor.author | Yoon, Ho Il | - |
dc.contributor.author | Sheen, Seung Soo | - |
dc.contributor.author | Kim, NamKug | - |
dc.contributor.author | Seo, Joon Beom | - |
dc.contributor.author | Oh, Yeon-Mok | - |
dc.contributor.author | Do Lee, Sang | - |
dc.date.accessioned | 2021-09-08T04:20:33Z | - |
dc.date.available | 2021-09-08T04:20:33Z | - |
dc.date.created | 2021-06-11 | - |
dc.date.issued | 2010-04 | - |
dc.identifier.issn | 0954-6111 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/116769 | - |
dc.description.abstract | Rationale: Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous disorder in which a number of different pathological processes lead to recognition of patient subgroups that may have individual characteristics and distinct responses to treatment. Objectives: We tested the hypothesis that responses of lung function to 3 months of combined inhalation of long-acting beta-agonist and corticosteroid might differ among patients with various COPD subtypes. Methods: We classified 165 COPD patients into four subtypes according to the severity of emphysema and airflow obstruction: emphysema-dominant, obstruction-dominant, mild-mixed, and severe-mixed. The emphysema-dominant subtype was defined by an emphysema index on computed tomography of more than 20% and FEV1 more than 45% of the predicted value. The obstruction-dominant subtype had an emphysema index <= 20% and FEV1 <= 45%, the mild-mixed subtype had an emphysema index <= 20% and FEV1 > 45%, and the severe-mixed subtype had an emphysema index > 20% and FEV1 <= 45%. Patients were recruited prospectively and treated with 3 months of combined inhalation of long-acting beta-agonist and corticosteroid. Results: After 3 months of combined inhalation of long-acting beta-agonist and corticosteroid, obstruction-dominant subtype patients showed a greater FEV1 increase and more marked dyspnea improvement than did the emphysema-dominant subgroup. The mixed-subtype patients (both subgroups) also showed significant improvement in FEV1 compared with the emphysema-dominant subgroup. Emphysema-dominant subtype patients showed no improvement in FEV1 or dyspnea after the 3-month treatment period. Conclusion: The responses to 3 months of combined inhalation of long-acting beta-agonist and corticosteroid differed according to COPD subtype. (C) 2009 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | W B SAUNDERS CO LTD | - |
dc.subject | OBSTRUCTIVE PULMONARY-DISEASE | - |
dc.subject | AIR-FLOW LIMITATION | - |
dc.subject | COMPUTED DENSITY | - |
dc.subject | EMPHYSEMA | - |
dc.subject | INFLAMMATION | - |
dc.subject | FLUTICASONE | - |
dc.subject | SALMETEROL | - |
dc.subject | AIRWAYS | - |
dc.subject | MORPHOMETRY | - |
dc.subject | DIMENSIONS | - |
dc.title | Responses to inhaled long-acting beta-agonist and corticosteroid according to COPD subtype | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Sangyeub | - |
dc.identifier.doi | 10.1016/j.rmed.2009.10.024 | - |
dc.identifier.wosid | 000276498700009 | - |
dc.identifier.bibliographicCitation | RESPIRATORY MEDICINE, v.104, no.4, pp.542 - 549 | - |
dc.relation.isPartOf | RESPIRATORY MEDICINE | - |
dc.citation.title | RESPIRATORY MEDICINE | - |
dc.citation.volume | 104 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 542 | - |
dc.citation.endPage | 549 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.subject.keywordPlus | OBSTRUCTIVE PULMONARY-DISEASE | - |
dc.subject.keywordPlus | AIR-FLOW LIMITATION | - |
dc.subject.keywordPlus | COMPUTED DENSITY | - |
dc.subject.keywordPlus | EMPHYSEMA | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | FLUTICASONE | - |
dc.subject.keywordPlus | SALMETEROL | - |
dc.subject.keywordPlus | AIRWAYS | - |
dc.subject.keywordPlus | MORPHOMETRY | - |
dc.subject.keywordPlus | DIMENSIONS | - |
dc.subject.keywordAuthor | COPD | - |
dc.subject.keywordAuthor | Subtype | - |
dc.subject.keywordAuthor | Inhaled long acting bronchodilator | - |
dc.subject.keywordAuthor | Corticosteroid | - |
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