TGF-beta-treated antigen presenting cells suppress collagen-induced arthritis through the promotion of Th2 responses
DC Field | Value | Language |
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dc.contributor.author | Jung, Sundo | - |
dc.contributor.author | Park, Yoon-Kyung | - |
dc.contributor.author | Lee, Hyunji | - |
dc.contributor.author | Shin, Jung Hoon | - |
dc.contributor.author | Lee, Gap Ryol | - |
dc.contributor.author | Park, Se-Ho | - |
dc.date.accessioned | 2021-09-08T04:26:50Z | - |
dc.date.available | 2021-09-08T04:26:50Z | - |
dc.date.created | 2021-06-11 | - |
dc.date.issued | 2010-03-31 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/116779 | - |
dc.description.abstract | Collagen-induced arthritis (CIA) is mediated by self-reactive CD4(+) T cells that produce inflammatory cytokines. TGF-beta(2)-treated tolerogenic antigen-presenting cells (Tol-APCs) are known to induce tolerance in various autoimmune diseases. In this study, we investigated whether collagen-specific Tol-APCs could induce suppression of CIA. We observed that Tol-APCs could suppress the development and severity of CIA and delay the onset of CIA. Treatment of Tol-APCs reduced the number of IFN-gamma- and IL-17-producing CD4(+) T cells and increased IL-4- and IL-5-producing CD4(+) T cells upon collagen antigen stimulation in vitro. The suppression of CIA conferred by Tol-APCs correlated with their ability to selectively induce IL-10 production. We also observed that treatment of Tol-APCs inhibited not only cellular immune responses but also humoral immune responses in the process of CIA. Our results suggest that in vitro-generated Tol-APCs have potential therapeutic value for the treatment of rheumatoid arthritis as well as other autoimmune diseases. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | IMMUNE DEVIATION ACAID | - |
dc.subject | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | - |
dc.subject | T-REGULATORY CELLS | - |
dc.subject | ANTERIOR-CHAMBER | - |
dc.subject | DENDRITIC CELLS | - |
dc.subject | SYSTEMIC TOLERANCE | - |
dc.subject | TOLEROGENIC APC | - |
dc.subject | MICE | - |
dc.subject | INDUCTION | - |
dc.subject | CYTOKINE | - |
dc.title | TGF-beta-treated antigen presenting cells suppress collagen-induced arthritis through the promotion of Th2 responses | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Se-Ho | - |
dc.identifier.doi | 10.3858/emm.2010.42.3.019 | - |
dc.identifier.scopusid | 2-s2.0-77950536695 | - |
dc.identifier.wosid | 000276279800004 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL AND MOLECULAR MEDICINE, v.42, no.3, pp.187 - 194 | - |
dc.relation.isPartOf | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.citation.title | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.citation.volume | 42 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 187 | - |
dc.citation.endPage | 194 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001428791 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | IMMUNE DEVIATION ACAID | - |
dc.subject.keywordPlus | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | - |
dc.subject.keywordPlus | T-REGULATORY CELLS | - |
dc.subject.keywordPlus | ANTERIOR-CHAMBER | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | SYSTEMIC TOLERANCE | - |
dc.subject.keywordPlus | TOLEROGENIC APC | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | CYTOKINE | - |
dc.subject.keywordAuthor | antigen-presenting cells | - |
dc.subject.keywordAuthor | arthritis, experimental | - |
dc.subject.keywordAuthor | autoimmune diseases | - |
dc.subject.keywordAuthor | immune tolerance | - |
dc.subject.keywordAuthor | Th1 cells | - |
dc.subject.keywordAuthor | Th2 cells | - |
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