Cytosolic Hsp60 Is Involved in the NF-kappa B-Dependent Survival of Cancer Cells via IKK Regulation
DC Field | Value | Language |
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dc.contributor.author | Chun, Jung Nyeo | - |
dc.contributor.author | Choi, Boae | - |
dc.contributor.author | Lee, Kyung Wha | - |
dc.contributor.author | Lee, Doo Jae | - |
dc.contributor.author | Kang, Dong Hoon | - |
dc.contributor.author | Lee, Joo Young | - |
dc.contributor.author | Song, In Sung | - |
dc.contributor.author | Kim, Hye In | - |
dc.contributor.author | Lee, Sang-Hee | - |
dc.contributor.author | Kim, Hyeon Soo | - |
dc.contributor.author | Lee, Na Kyung | - |
dc.contributor.author | Lee, Soo Young | - |
dc.contributor.author | Lee, Kong-Joo | - |
dc.contributor.author | Kim, Jaesang | - |
dc.contributor.author | Kang, Sang Won | - |
dc.date.accessioned | 2021-09-08T04:28:19Z | - |
dc.date.available | 2021-09-08T04:28:19Z | - |
dc.date.created | 2021-06-11 | - |
dc.date.issued | 2010-03-23 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/116787 | - |
dc.description.abstract | Cytoplasmic presence of Hsp60, which is principally a nuclear gene-encoded mitochondrial chaperonin, has frequently been stated, but its role in intracellular signaling is largely unknown. In this study, we demonstrate that the cytosolic Hsp60 promotes the TNF-alpha-mediated activation of the IKK/NF-kappa B survival pathway via direct interaction with IKK alpha/beta in the cytoplasm. Selective loss or blockade of cytosolic Hsp60 by specific antisense oligonucleotide or neutralizing antibody diminished the IKK/NF-kappa B activation and the expression of NF-kappa B target genes, such as Bfl-1/A1 and MnSOD, which thus augmented intracellular ROS production and ASK1-dependent cell death, in response to TNF-alpha. Conversely, the ectopic expression of cytosol-targeted Hsp60 enhanced IKK/NF-kappa B activation. Mechanistically, the cytosolic Hsp60 enhanced IKK activation via upregulating the activation-dependent serine phosphorylation in a chaperone-independent manner. Furthermore, transgenic mouse study showed that the cytosolic Hsp60 suppressed hepatic cell death induced by diethylnitrosamine in vivo. The cytosolic Hsp60 is likely to be a regulatory component of IKK complex and it implicates the first mitochondrial factor that regulates cell survival via NF-kappa B pathway. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.subject | TUMOR-NECROSIS-FACTOR | - |
dc.subject | HEAT-SHOCK-PROTEIN | - |
dc.subject | KINASE-ALPHA | - |
dc.subject | OSTEOCLAST DIFFERENTIATION | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | CHAPERONIN GROEL | - |
dc.subject | SERINE-PROTEASE | - |
dc.subject | ACTIVATION | - |
dc.subject | APOPTOSIS | - |
dc.subject | COMPLEX | - |
dc.title | Cytosolic Hsp60 Is Involved in the NF-kappa B-Dependent Survival of Cancer Cells via IKK Regulation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hyeon Soo | - |
dc.identifier.doi | 10.1371/journal.pone.0009422 | - |
dc.identifier.scopusid | 2-s2.0-79952116841 | - |
dc.identifier.wosid | 000275894400003 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.5, no.3 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 5 | - |
dc.citation.number | 3 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | TUMOR-NECROSIS-FACTOR | - |
dc.subject.keywordPlus | HEAT-SHOCK-PROTEIN | - |
dc.subject.keywordPlus | KINASE-ALPHA | - |
dc.subject.keywordPlus | OSTEOCLAST DIFFERENTIATION | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | CHAPERONIN GROEL | - |
dc.subject.keywordPlus | SERINE-PROTEASE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | COMPLEX | - |
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