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Synthesis and bradykinin inhibitory activity of novel non-peptide compounds, and evaluation of in vivo analgesic activity

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dc.contributor.authorKam, Yoo Lim-
dc.contributor.authorRhee, Hee-Kyung-
dc.contributor.authorKim, Hwa-Jung-
dc.contributor.authorBack, Seung Keun-
dc.contributor.authorNa, Heung Sik-
dc.contributor.authorChoo, Hea-Young Park-
dc.date.accessioned2021-09-08T04:33:45Z-
dc.date.available2021-09-08T04:33:45Z-
dc.date.created2021-06-11-
dc.date.issued2010-03-15-
dc.identifier.issn0968-0896-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/116810-
dc.description.abstractA series of novel non-peptide diamide compounds was synthesized and evaluated as antibradykinin agents by utilizing guinea-pig ileum smooth muscle. Among the final compounds, (Z)-4-(4-(bis(4-fluorophenyl) methyl)piperazin-1-yl)-4-oxo-N-(4-phenylbutan-2-yl)but-2-enamide showed most favorable bradykinin inhibitory activity and demonstrated analgesic efficacies in the rat models of inflammatory and neuropathic pain. (C) 2010 Published by Elsevier Ltd.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectGUINEA-PIG ILEUM-
dc.subjectFORMALIN TEST-
dc.subjectNEUROPATHIC PAIN-
dc.subjectKININ RECEPTORS-
dc.subjectNERVE INJURY-
dc.subjectMECHANICAL ALLODYNIA-
dc.subjectINFLAMMATORY PAIN-
dc.subjectOPIOID MODULATION-
dc.subjectTACTILE ALLODYNIA-
dc.subjectB1 RECEPTORS-
dc.titleSynthesis and bradykinin inhibitory activity of novel non-peptide compounds, and evaluation of in vivo analgesic activity-
dc.typeArticle-
dc.contributor.affiliatedAuthorNa, Heung Sik-
dc.identifier.doi10.1016/j.bmc.2010.01.050-
dc.identifier.scopusid2-s2.0-77649238323-
dc.identifier.wosid000275513700029-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY, v.18, no.6, pp.2327 - 2336-
dc.relation.isPartOfBIOORGANIC & MEDICINAL CHEMISTRY-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY-
dc.citation.volume18-
dc.citation.number6-
dc.citation.startPage2327-
dc.citation.endPage2336-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.subject.keywordPlusGUINEA-PIG ILEUM-
dc.subject.keywordPlusFORMALIN TEST-
dc.subject.keywordPlusNEUROPATHIC PAIN-
dc.subject.keywordPlusKININ RECEPTORS-
dc.subject.keywordPlusNERVE INJURY-
dc.subject.keywordPlusMECHANICAL ALLODYNIA-
dc.subject.keywordPlusINFLAMMATORY PAIN-
dc.subject.keywordPlusOPIOID MODULATION-
dc.subject.keywordPlusTACTILE ALLODYNIA-
dc.subject.keywordPlusB1 RECEPTORS-
dc.subject.keywordAuthorAntibradykinin agents-
dc.subject.keywordAuthorFormalin test-
dc.subject.keywordAuthorAllodynia-
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