Anti-fibrotic effect of thalidomide through inhibiting TGF-beta-induced ERK1/2 pathways in bleomycin-induced lung fibrosis in mice
DC Field | Value | Language |
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dc.contributor.author | Choe, Jung-Yoon | - |
dc.contributor.author | Jung, Hyun-Joo | - |
dc.contributor.author | Park, Ki-Yeun | - |
dc.contributor.author | Kum, Yoon-Seup | - |
dc.contributor.author | Song, Gwan Gyu | - |
dc.contributor.author | Hyun, Dae-Sung | - |
dc.contributor.author | Park, Sung-Hoon | - |
dc.contributor.author | Kim, Seong-Kyu | - |
dc.date.accessioned | 2021-09-08T04:39:44Z | - |
dc.date.available | 2021-09-08T04:39:44Z | - |
dc.date.created | 2021-06-11 | - |
dc.date.issued | 2010-03 | - |
dc.identifier.issn | 1023-3830 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/116839 | - |
dc.description.abstract | This study is designed to confirm the anti-fibrotic effect of thalidomide on bleomycin-induced lung fibrosis in a mouse model and to identify whether this anti-fibrotic effect is associated with inhibition of the transforming growth factor-beta (TGF-beta)-induced extracellular signal-regulated kinase1/2 (ERK1/2). C57BL/6 female mice were administered blomycin sulfate. In cultured human lung fibroblasts, expressions of type I collagen, fibronectin, and either TGF-beta or IL-6 were measured after thalidomide treatment by reverse transcription-polymerase chain reaction (RT-PCR). Expressions of ERK1/2, type I collagen, fibronectin, and TGF-beta 1 from lung tissues of blomycin-induced mice and from mouse lung fibroblasts were evaluated using RT-PCR and western blotting. Thalidomide administration significantly inhibits TGF-beta 1 mRNA expression in a dose-dependant manner following administration of IL-6 and IL-6R. In the analysis of BAL fluids, total BAL inflammatory cell counts, TGF-beta 1, and IL-6 levels in thalidomide-treated mice were significantly reduced when compared with bleomycin-treated mice (p < 0.01, p < 0.01, and p < 0.001, respectively). Thalidomide inhibited total ERK1/2 and phospho-ERK1/2 expression after TGF-beta 1 stimulation in the RT-PCR and western blotting. The results of our study suggest that the anti-fibrotic effect of thalidomide on lung fibrosis may be related to suppression of the TGF-beta 1-induced ERK1/2 signaling pathway. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER BASEL AG | - |
dc.subject | IDIOPATHIC PULMONARY-FIBROSIS | - |
dc.subject | GROWTH-FACTOR-BETA | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | TNF-ALPHA | - |
dc.subject | RESPONSES | - |
dc.subject | DISEASE | - |
dc.subject | RATS | - |
dc.title | Anti-fibrotic effect of thalidomide through inhibiting TGF-beta-induced ERK1/2 pathways in bleomycin-induced lung fibrosis in mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.identifier.doi | 10.1007/s00011-009-0084-9 | - |
dc.identifier.scopusid | 2-s2.0-77749340411 | - |
dc.identifier.wosid | 000274331800002 | - |
dc.identifier.bibliographicCitation | INFLAMMATION RESEARCH, v.59, no.3, pp.177 - 188 | - |
dc.relation.isPartOf | INFLAMMATION RESEARCH | - |
dc.citation.title | INFLAMMATION RESEARCH | - |
dc.citation.volume | 59 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 177 | - |
dc.citation.endPage | 188 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | IDIOPATHIC PULMONARY-FIBROSIS | - |
dc.subject.keywordPlus | GROWTH-FACTOR-BETA | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | TNF-ALPHA | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordAuthor | Thalidomide | - |
dc.subject.keywordAuthor | Bleomycin | - |
dc.subject.keywordAuthor | Lung | - |
dc.subject.keywordAuthor | Fibrosis | - |
dc.subject.keywordAuthor | TGF-beta | - |
dc.subject.keywordAuthor | ERK1/2 | - |
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