Modification of mesenchymal stem cells for cardiac regeneration
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song, Heesang | - |
dc.contributor.author | Song, Byeong-Wook | - |
dc.contributor.author | Cha, Min-Ji | - |
dc.contributor.author | Choi, In-Geol | - |
dc.contributor.author | Hwang, Ki-Chul | - |
dc.date.accessioned | 2021-09-08T04:44:42Z | - |
dc.date.available | 2021-09-08T04:44:42Z | - |
dc.date.created | 2021-06-11 | - |
dc.date.issued | 2010-03 | - |
dc.identifier.issn | 1471-2598 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/116867 | - |
dc.description.abstract | Importance of the field. Mesenchymal stem cells (MSCs) have the greatest potential for use in cell-based therapy of human heart diseases, especially in myocardial infarcts. The therapeutic potential of MSCs in myocardial repair is based on the ability of MSCs to directly differentiate into cardiac tissue and on the paracrine actions of factors released from MSCs. However, the major obstacle in the clinical application of MSC-based therapy is the poor viability of the transplanted cells due to harsh microenvironments like ischemia, inflammation and/or anoikis in the infarcted myocardium. Recently, various approaches have been implemented in an effort to improve the survival of implanted MSCs through ex vivo manipulation of MSCs. Areas covered in this review. Major obstacles in MSC-based therapy are discussed, along with recent advances for enhancing therapeutic potential of engrafted MSCs from the past decade. What the reader will gain: This review focuses primarily on ex vivo manipulation of MSCs before transplantation, which includes pretreatment, preconditioning and genetic modification of MSCs, and future directions. Take home message: Modification of MSCs before transplantation has developed into a promising option for enhancing the beneficial effects of MSC-based therapy for cardiac repair after myocardial infarction. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.subject | INTEGRIN-LINKED KINASE | - |
dc.subject | ENDOTHELIAL PROGENITOR CELLS | - |
dc.subject | BONE-MARROW | - |
dc.subject | GROWTH-FACTOR | - |
dc.subject | STROMAL CELLS | - |
dc.subject | INTRACORONARY TRANSPLANTATION | - |
dc.subject | TISSUE TRANSGLUTAMINASE | - |
dc.subject | ISCHEMIC-MYOCARDIUM | - |
dc.subject | HEART-FAILURE | - |
dc.subject | IN-VITRO | - |
dc.title | Modification of mesenchymal stem cells for cardiac regeneration | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, In-Geol | - |
dc.identifier.doi | 10.1517/14712590903455997 | - |
dc.identifier.scopusid | 2-s2.0-76949087876 | - |
dc.identifier.wosid | 000275094200002 | - |
dc.identifier.bibliographicCitation | EXPERT OPINION ON BIOLOGICAL THERAPY, v.10, no.3, pp.309 - 319 | - |
dc.relation.isPartOf | EXPERT OPINION ON BIOLOGICAL THERAPY | - |
dc.citation.title | EXPERT OPINION ON BIOLOGICAL THERAPY | - |
dc.citation.volume | 10 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 309 | - |
dc.citation.endPage | 319 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | INTEGRIN-LINKED KINASE | - |
dc.subject.keywordPlus | ENDOTHELIAL PROGENITOR CELLS | - |
dc.subject.keywordPlus | BONE-MARROW | - |
dc.subject.keywordPlus | GROWTH-FACTOR | - |
dc.subject.keywordPlus | STROMAL CELLS | - |
dc.subject.keywordPlus | INTRACORONARY TRANSPLANTATION | - |
dc.subject.keywordPlus | TISSUE TRANSGLUTAMINASE | - |
dc.subject.keywordPlus | ISCHEMIC-MYOCARDIUM | - |
dc.subject.keywordPlus | HEART-FAILURE | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordAuthor | cardiac regenration | - |
dc.subject.keywordAuthor | cell adhesion | - |
dc.subject.keywordAuthor | cell survival | - |
dc.subject.keywordAuthor | mesenchymal stem cell | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
145 Anam-ro, Seongbuk-gu, Seoul, 02841, Korea+82-2-3290-2963
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.