Gemcitabine and oxaliplatin in patients with unresectable biliary cancer including gall bladder cancer: a Korean Cancer Study Group phase II trial
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jang, Joung-Soon | - |
dc.contributor.author | Lim, Ho Yeong | - |
dc.contributor.author | Hwang, In Gyu | - |
dc.contributor.author | Song, Hong Suk | - |
dc.contributor.author | Yoo, NaeChoon | - |
dc.contributor.author | Yoon, SoYoung | - |
dc.contributor.author | Kim, Yeul Hong | - |
dc.contributor.author | Park, Eunsik | - |
dc.contributor.author | Byun, Jae Ho | - |
dc.contributor.author | Lee, Myung Ah | - |
dc.contributor.author | Oh, Suk Joong | - |
dc.contributor.author | Lee, Kyung Hee | - |
dc.contributor.author | Kim, Bong Seog | - |
dc.contributor.author | Oh, Sang Cheul | - |
dc.contributor.author | Kim, Sam Yong | - |
dc.contributor.author | Lee, Sang Jae | - |
dc.date.accessioned | 2021-09-08T04:55:36Z | - |
dc.date.available | 2021-09-08T04:55:36Z | - |
dc.date.created | 2021-06-11 | - |
dc.date.issued | 2010-03 | - |
dc.identifier.issn | 0344-5704 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/116929 | - |
dc.description.abstract | Chemotherapy represents a palliative treatment, with poor response rates and a median survival of less than 6 months in patients with biliary tract cancers (BTCs). The aim of this study was to evaluate the efficacy and safety of the combination chemotherapy with gemcitabine and oxaliplatin (GEMOX) in patients with BTCs including gall bladder cancer. We carried out a nationwide multicenter phase II study evaluated the efficacy and safety of GEMOX as first-line therapy in patients with advanced BTCs. Eligible patients with previously untreated locally advanced or metastatic BTCs received gemcitabine 1,000 mg/m(2) (day 1 and 8) and oxaliplatin 100 mg/m(2) (day 1), every 3 weeks. Fifty-three patients were evaluated, 60% had cholangiocarcinoma and the remaining 40% gall bladder cancer; the objective response rate was 18.9% (10/53 patients including 1 Complete response) [14.9%; 95% confidence interval (CI), 7.4-25.7%] in the treated population. Stable disease were observed in 27/53 (50.9%) patients, disease control rate was achieved in 69.8% of all patients. Median progression-free survival was 4.8 months (3.1-6.5, 95% CI) and median overall survival was 8.3 months (5.8-10.8, 95% CI). Grade 3/4 toxicities included neutropenia (33.9% of patients) and thrombocytopenia (7.6%). The GEMOX regimen demonstrated a modest antitumor activity and is well tolerated in patients with advanced BTCs. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | TRACT CARCINOMA | - |
dc.subject | CHEMOTHERAPY | - |
dc.subject | CISPLATIN | - |
dc.subject | GALLBLADDER | - |
dc.title | Gemcitabine and oxaliplatin in patients with unresectable biliary cancer including gall bladder cancer: a Korean Cancer Study Group phase II trial | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yeul Hong | - |
dc.contributor.affiliatedAuthor | Oh, Sang Cheul | - |
dc.identifier.doi | 10.1007/s00280-009-1069-7 | - |
dc.identifier.scopusid | 2-s2.0-75749113721 | - |
dc.identifier.wosid | 000273786500003 | - |
dc.identifier.bibliographicCitation | CANCER CHEMOTHERAPY AND PHARMACOLOGY, v.65, no.4, pp.641 - 647 | - |
dc.relation.isPartOf | CANCER CHEMOTHERAPY AND PHARMACOLOGY | - |
dc.citation.title | CANCER CHEMOTHERAPY AND PHARMACOLOGY | - |
dc.citation.volume | 65 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 641 | - |
dc.citation.endPage | 647 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | TRACT CARCINOMA | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | CISPLATIN | - |
dc.subject.keywordPlus | GALLBLADDER | - |
dc.subject.keywordAuthor | Biliary tract cancers | - |
dc.subject.keywordAuthor | Chemotherapy | - |
dc.subject.keywordAuthor | Gemcitabine | - |
dc.subject.keywordAuthor | Oxaliplatin | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.