CK beta 8/CCL23 induces cell migration via the G(i)/G(o) protein/PLC/PKC delta/NF-kappa B and is involved in inflammatory responses
DC Field | Value | Language |
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dc.contributor.author | Kim, Jeonghan | - |
dc.contributor.author | Kim, Yoon Suk | - |
dc.contributor.author | Ko, Jesang | - |
dc.date.accessioned | 2021-09-08T05:04:00Z | - |
dc.date.available | 2021-09-08T05:04:00Z | - |
dc.date.created | 2021-06-11 | - |
dc.date.issued | 2010-02-27 | - |
dc.identifier.issn | 0024-3205 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/116971 | - |
dc.description.abstract | Aims: CK beta 8/CCL23 is a CC chemokine and alternative splicing of the CK beta 8 gene produces two mRNAs that encode CK beta 8 and its isoform CK beta 8-1. Although it has been reported that CK beta 8 and CK beta 8-1 are implicated in leukocyte trafficking and development of inflammation, the exact roles of these two chemokines in immune responses and the associated chemotaxis signaling are still obscure. Main methods: To understand the mechanism of CK beta 8- and CK beta 8-1-induced chemotaxis signaling, we examined the chemotactic activities of osteogenic sarcoma cells expressing CC chemokine receptor I in response to CK beta 8 and CK beta 8-1. We also examined involvement of CK beta 8 and CK beta 8-1 in inflammatory responses by determining the mRNA expression of pro-inflammatory molecules induced by two chemokines and expressions of these chemokines in foam cells. Key findings: Results from a chemotaxis assay using various inhibitors for signaling molecules showed that the chemotaxis signal pathway induced by both CK beta 8 and CK beta 8-1 was mediated via the G(i)/G(o) protein, phospholipase C (PLC) and protein kinase C delta (PKC delta). Treatment with a nuclear factor kappa B (NF-kappa B) inhibitor reduced the chemotactic activities of CK beta 8 and CK beta 8-1, and NF-kappa B was activated in response to CK beta 8 and CK beta 8-1. In addition, CK beta 8 and CK beta 8-1 increased mRNA expression of pro-inflammatory cytokines and adhesion molecules. The mRNA levels of CK beta 8 and CK beta 8-1 were increased in foam cells. Significance: These results indicate that both CK beta 8 and CK beta 8-1 transduce the chemotaxis signal through the G(i)/G(o) protein, PLC, PKC delta, and NF-kappa B, and that CK beta 8 and CK beta 8-1 probably play important roles in inflammatory diseases such as atherosclerosis. (C) 2009 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | CC-CHEMOKINE | - |
dc.subject | ADHESION MOLECULES | - |
dc.subject | AMINO-ACID | - |
dc.subject | RECEPTOR | - |
dc.subject | IDENTIFICATION | - |
dc.subject | LEUKOTACTIN-1 | - |
dc.subject | INHIBITION | - |
dc.subject | ACTIVATION | - |
dc.subject | EXPRESSION | - |
dc.subject | CYTOKINES | - |
dc.title | CK beta 8/CCL23 induces cell migration via the G(i)/G(o) protein/PLC/PKC delta/NF-kappa B and is involved in inflammatory responses | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ko, Jesang | - |
dc.identifier.doi | 10.1016/j.lfs.2009.11.012 | - |
dc.identifier.scopusid | 2-s2.0-76849112481 | - |
dc.identifier.wosid | 000274909900002 | - |
dc.identifier.bibliographicCitation | LIFE SCIENCES, v.86, no.9-10, pp.300 - 308 | - |
dc.relation.isPartOf | LIFE SCIENCES | - |
dc.citation.title | LIFE SCIENCES | - |
dc.citation.volume | 86 | - |
dc.citation.number | 9-10 | - |
dc.citation.startPage | 300 | - |
dc.citation.endPage | 308 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | CC-CHEMOKINE | - |
dc.subject.keywordPlus | ADHESION MOLECULES | - |
dc.subject.keywordPlus | AMINO-ACID | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | LEUKOTACTIN-1 | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CYTOKINES | - |
dc.subject.keywordAuthor | CK beta 8 | - |
dc.subject.keywordAuthor | Chemokine | - |
dc.subject.keywordAuthor | Chemotaxis | - |
dc.subject.keywordAuthor | Atherosclerosis | - |
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