Ras-induced invasion and metastasis are regulated by a leukotriene B-4 receptor BLT2-linked pathway
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, E-Y | - |
dc.contributor.author | Seo, J-M | - |
dc.contributor.author | Cho, K-J | - |
dc.contributor.author | Kim, J-H | - |
dc.date.accessioned | 2021-09-08T05:04:21Z | - |
dc.date.available | 2021-09-08T05:04:21Z | - |
dc.date.created | 2021-06-11 | - |
dc.date.issued | 2010-02-25 | - |
dc.identifier.issn | 0950-9232 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/116973 | - |
dc.description.abstract | Ras signaling pathways are well-recognized for their involvement in cancer cell proliferation; however, considerably less is known regarding their contribution to invasion and metastasis. Here, we demonstrate that a novel BLT2, a low-affinity leukotriene B-4 receptor-linked signaling cascade involving the generation of reactive oxygen species (ROS) via Nox1, NF-kappa B stimulation and subsequent upregulation of matrix metalloproteinase-9 (MMP-9) is a potential mechanism by which Ras promotes invasion and metastasis. We found that inhibition of BLT2 signaling markedly suppressed Ras-evoked metastasis and reduced the associated mortality in mice. Consistent with the proposed role of BLT2 as a key downstream mediator of Ras signaling to metastasis, BLT2 expression alone resulted in the formation of numerous metastatic lung nodules and the nodules formation was significantly attenuated by the inhibition of MMP-9, a downstream component of BLT2. Together, our results reveal the previously unsuspected function of BLT2-linked cascade in driving oncogenic Ras-induced metastasis and would provide a valuable insight into invasion and metastasis. Oncogene (2010) 29, 1167-1178; doi: 10.1038/onc.2009.412; published online 23 November 2009 | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | PANCREATIC-CANCER | - |
dc.subject | ONCOGENIC RAS | - |
dc.subject | H-RAS | - |
dc.subject | EXPRESSION | - |
dc.subject | CYCLOOXYGENASE-2 | - |
dc.subject | PROLIFERATION | - |
dc.subject | ACTIVATION | - |
dc.subject | MIGRATION | - |
dc.subject | MECHANISM | - |
dc.title | Ras-induced invasion and metastasis are regulated by a leukotriene B-4 receptor BLT2-linked pathway | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, J-H | - |
dc.identifier.doi | 10.1038/onc.2009.412 | - |
dc.identifier.scopusid | 2-s2.0-77649184896 | - |
dc.identifier.wosid | 000274912100008 | - |
dc.identifier.bibliographicCitation | ONCOGENE, v.29, no.8, pp.1167 - 1178 | - |
dc.relation.isPartOf | ONCOGENE | - |
dc.citation.title | ONCOGENE | - |
dc.citation.volume | 29 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1167 | - |
dc.citation.endPage | 1178 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | PANCREATIC-CANCER | - |
dc.subject.keywordPlus | ONCOGENIC RAS | - |
dc.subject.keywordPlus | H-RAS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CYCLOOXYGENASE-2 | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | MIGRATION | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordAuthor | H-Ras | - |
dc.subject.keywordAuthor | leukotriene B-4 receptor BLT2 | - |
dc.subject.keywordAuthor | ROS | - |
dc.subject.keywordAuthor | metastasis | - |
dc.subject.keywordAuthor | MMP-9 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.