RETRACTED: Direct interaction of cellular hnRNP-F and NS1 of influenza A virus accelerates viral replication by modulation of viral transcriptional activity and host gene expression (Retracted article. See vol. 436, pg. 245, 2013)
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jun Han | - |
dc.contributor.author | Kim, Sung-Hak | - |
dc.contributor.author | Pascua, Philippe Noriel Q. | - |
dc.contributor.author | Song, Min-Suk | - |
dc.contributor.author | Baek, Yun Hee | - |
dc.contributor.author | Jin, Xun | - |
dc.contributor.author | Choi, Joong-Kook | - |
dc.contributor.author | Kim, Chul-Joong | - |
dc.contributor.author | Kim, Hyunggee | - |
dc.contributor.author | Choi, Young Ki | - |
dc.date.accessioned | 2021-09-08T05:09:08Z | - |
dc.date.available | 2021-09-08T05:09:08Z | - |
dc.date.created | 2021-06-11 | - |
dc.date.issued | 2010-02-05 | - |
dc.identifier.issn | 0042-6822 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/116999 | - |
dc.description.abstract | To investigate novel NS1-interacting proteins, we conducted a yeast two-hybrid analysis, followed by co-immunoprecipitation assays. We identified heterogeneous nuclear ribonucleoprotein F (hnRNP-F) as a Cellular protein interacting with NS1 during influenza A virus infection. Co-precipitation assays suggest that interaction between hnRNP-F and NS1 is a common and direct event among human or avian influenza viruses. NS1 and hnRNP-F co-localize in the nucleus of host cells, and the RNA-binding domain of NS1 directly interacts with the GY-rich region of hnRNP-F determined by GST pull-down assays with truncated proteins. Importantly, hnRNP-F expression levels in host cells indicate regulatory role on virus replication. hnRNP-F depletion by small interfering RNA (siRNA) shows 10- to 100-fold increases in virus titers corresponding to enhanced viral RNA polymerase activity. Our results delineate novel mechanism of action by which NS1 accelerates influenza virus replication by modulating normal cellular mRNA processes through direct interaction with cellular hnRNP-F protein. (C) 2009 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | RNA-BINDING PROTEINS | - |
dc.subject | PRE-MESSENGER-RNAS | - |
dc.subject | DOUBLE-STRANDED-RNA | - |
dc.subject | TRANSLATION INITIATION | - |
dc.subject | NUCLEAR EXPORT | - |
dc.subject | INFECTED-CELLS | - |
dc.subject | NUCLEOCYTOPLASMIC TRANSPORT | - |
dc.subject | POLYMERASE COMPLEX | - |
dc.subject | EFFECTOR DOMAIN | - |
dc.subject | SITE | - |
dc.title | RETRACTED: Direct interaction of cellular hnRNP-F and NS1 of influenza A virus accelerates viral replication by modulation of viral transcriptional activity and host gene expression (Retracted article. See vol. 436, pg. 245, 2013) | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Sung-Hak | - |
dc.contributor.affiliatedAuthor | Jin, Xun | - |
dc.contributor.affiliatedAuthor | Kim, Hyunggee | - |
dc.identifier.doi | 10.1016/j.virol.2009.10.041 | - |
dc.identifier.scopusid | 2-s2.0-73949148579 | - |
dc.identifier.wosid | 000274132700011 | - |
dc.identifier.bibliographicCitation | VIROLOGY, v.397, no.1, pp.89 - 99 | - |
dc.relation.isPartOf | VIROLOGY | - |
dc.citation.title | VIROLOGY | - |
dc.citation.volume | 397 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 89 | - |
dc.citation.endPage | 99 | - |
dc.type.rims | ART | - |
dc.type.docType | Article; Retracted Publication | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Virology | - |
dc.relation.journalWebOfScienceCategory | Virology | - |
dc.subject.keywordPlus | RNA-BINDING PROTEINS | - |
dc.subject.keywordPlus | PRE-MESSENGER-RNAS | - |
dc.subject.keywordPlus | DOUBLE-STRANDED-RNA | - |
dc.subject.keywordPlus | TRANSLATION INITIATION | - |
dc.subject.keywordPlus | NUCLEAR EXPORT | - |
dc.subject.keywordPlus | INFECTED-CELLS | - |
dc.subject.keywordPlus | NUCLEOCYTOPLASMIC TRANSPORT | - |
dc.subject.keywordPlus | POLYMERASE COMPLEX | - |
dc.subject.keywordPlus | EFFECTOR DOMAIN | - |
dc.subject.keywordPlus | SITE | - |
dc.subject.keywordAuthor | hnRNP-F | - |
dc.subject.keywordAuthor | Immunoprecipitation | - |
dc.subject.keywordAuthor | Influenza A virus | - |
dc.subject.keywordAuthor | NS1 | - |
dc.subject.keywordAuthor | Virus replication | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.