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The Effect of Spatially Inhomogeneous Extracellular Electric Fields on Neurons

Authors
Anastassiou, Costas A.Montgomery, Sean M.Barahona, MauricioBuzsaki, GyoergyKoch, Christof
Issue Date
3-2월-2010
Publisher
SOC NEUROSCIENCE
Citation
JOURNAL OF NEUROSCIENCE, v.30, no.5, pp.1925 - 1936
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF NEUROSCIENCE
Volume
30
Number
5
Start Page
1925
End Page
1936
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/117003
DOI
10.1523/JNEUROSCI.3635-09.2010
ISSN
0270-6474
Abstract
The cooperative action of neurons and glia generates electrical fields, but their effect on individual neurons via ephaptic interactions is mostly unknown. Here, we analyze the impact of spatially inhomogeneous electric fields on the membrane potential, the induced membrane field, and the induced current source density of one-dimensional cables as well as morphologically realistic neurons and discuss how the features of the extracellular field affect these quantities. We show through simulations that endogenous fields, associated with hippocampal theta and sharp waves, can greatly affect spike timing. These findings imply that local electric fields, generated by the cooperative action of brain cells, can influence the timing of neural activity.
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