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Discovery of cyclicsulfonamide derivatives as 11 beta-hydroxysteroid dehydrogenase 1 inhibitors

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dc.contributor.authorKim, Se Hoan-
dc.contributor.authorRamu, Ravirala-
dc.contributor.authorKwon, Sung Wook-
dc.contributor.authorLee, Su-Hee-
dc.contributor.authorKim, Chi Hyun-
dc.contributor.authorKang, Seung Kyu-
dc.contributor.authorRhee, Sang Dal-
dc.contributor.authorBae, Myung Ae-
dc.contributor.authorAhn, Sung Hoon-
dc.contributor.authorHa, Duck Chan-
dc.contributor.authorCheon, Hyae Gyeong-
dc.contributor.authorKim, Ki Young-
dc.contributor.authorAhn, Jin Hee-
dc.date.accessioned2021-09-08T05:10:42Z-
dc.date.available2021-09-08T05:10:42Z-
dc.date.created2021-06-11-
dc.date.issued2010-02-01-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/117007-
dc.description.abstractA new series of cyclic sulfonamide derivatives was synthesized and evaluated for their ability to inhibit 11 beta-HSD1. Cyclic sulfonamides with phenylacetyl substituents at the 2-position showed nanomolar inhibitory activities. Among them, compound 4e exhibited a good in vitro inhibitory activity and selectivity toward human 11 beta-HSD2. (C) 2009 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectSELECTIVE INHIBITORS-
dc.subjectMETABOLIC SYNDROME-
dc.subjectVISCERAL OBESITY-
dc.subjectTYPE-1-
dc.subjectMICE-
dc.subjectPOTENT-
dc.titleDiscovery of cyclicsulfonamide derivatives as 11 beta-hydroxysteroid dehydrogenase 1 inhibitors-
dc.typeArticle-
dc.contributor.affiliatedAuthorHa, Duck Chan-
dc.identifier.doi10.1016/j.bmcl.2009.12.035-
dc.identifier.scopusid2-s2.0-74049154856-
dc.identifier.wosid000273783800061-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.20, no.3, pp.1065 - 1069-
dc.relation.isPartOfBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.volume20-
dc.citation.number3-
dc.citation.startPage1065-
dc.citation.endPage1069-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.subject.keywordPlusSELECTIVE INHIBITORS-
dc.subject.keywordPlusMETABOLIC SYNDROME-
dc.subject.keywordPlusVISCERAL OBESITY-
dc.subject.keywordPlusTYPE-1-
dc.subject.keywordPlusMICE-
dc.subject.keywordPlusPOTENT-
dc.subject.keywordAuthor11 beta-Hydroxysteroid dehydrogenase 1-
dc.subject.keywordAuthorCyclic sulfonamide-
dc.subject.keywordAuthorDiabetes-
dc.subject.keywordAuthorInhibitor-
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