Serum deprivation-induced reactive oxygen species production is mediated by Romo1
DC Field | Value | Language |
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dc.contributor.author | Lee, Seung Baek | - |
dc.contributor.author | Kim, Jung Jin | - |
dc.contributor.author | Kim, Tae Woo | - |
dc.contributor.author | Kim, Byung Soo | - |
dc.contributor.author | Lee, Myeong-Sok | - |
dc.contributor.author | Yoo, Young Do | - |
dc.date.accessioned | 2021-09-08T05:21:15Z | - |
dc.date.available | 2021-09-08T05:21:15Z | - |
dc.date.created | 2021-06-11 | - |
dc.date.issued | 2010-02 | - |
dc.identifier.issn | 1360-8185 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/117054 | - |
dc.description.abstract | Serum deprivation-triggered increases in reactive oxygen species (ROS) are known to induce apoptotic cell death. However, the mechanism by which serum deprivation causes ROS production is not known. Since mitochondria are the main source of ROS and since mitochondrial ROS modulator 1 (Romo1) is involved in ROS production, we sought to determine if serum deprivation triggered ROS production through Romo1. To examine the relationship between Romo1 and the serum deprivation-triggered increase in ROS, we transfected Romo1 siRNA into various cell lines and looked for inhibition of mitochondrial ROS generation. Romo1 knockdown by Romo1 siRNA blocked the mitochondrial ROS production caused by serum deprivation, which originates in the mitochondrial electron transport chain. We also found that Romo1 knockdown inhibited serum deprivation-induced apoptosis. These findings suggest that Romo1-derived ROS play an important role in apoptotic cell death triggered by withdrawal of cell survival factors. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | CELL-DEATH | - |
dc.subject | SIGNALING PATHWAYS | - |
dc.subject | INDUCED APOPTOSIS | - |
dc.subject | NEURONAL CELLS | - |
dc.subject | FREE-RADICALS | - |
dc.subject | CYTOCHROME-C | - |
dc.subject | MITOCHONDRIA | - |
dc.subject | ROS | - |
dc.subject | PROLIFERATION | - |
dc.title | Serum deprivation-induced reactive oxygen species production is mediated by Romo1 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Tae Woo | - |
dc.contributor.affiliatedAuthor | Kim, Byung Soo | - |
dc.contributor.affiliatedAuthor | Yoo, Young Do | - |
dc.identifier.doi | 10.1007/s10495-009-0411-1 | - |
dc.identifier.scopusid | 2-s2.0-77949264281 | - |
dc.identifier.wosid | 000274086900009 | - |
dc.identifier.bibliographicCitation | APOPTOSIS, v.15, no.2, pp.204 - 218 | - |
dc.relation.isPartOf | APOPTOSIS | - |
dc.citation.title | APOPTOSIS | - |
dc.citation.volume | 15 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 204 | - |
dc.citation.endPage | 218 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | CELL-DEATH | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | NEURONAL CELLS | - |
dc.subject.keywordPlus | FREE-RADICALS | - |
dc.subject.keywordPlus | CYTOCHROME-C | - |
dc.subject.keywordPlus | MITOCHONDRIA | - |
dc.subject.keywordPlus | ROS | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordAuthor | Reactive oxygen species | - |
dc.subject.keywordAuthor | Romo1 | - |
dc.subject.keywordAuthor | Serum deprivation | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | Mitochondria | - |
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