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Fabrication of three-dimensional microarray structures by controlling the thickness and elasticity of poly (dimethylsiloxane) membrane

Authors
Lee, Dae HoPark, Joong YullLee, Eun-JoongChoi, Yoon YoungKwon, Gu HanKim, Beop-MinLee, Sang-Hoon
Issue Date
2월-2010
Publisher
SPRINGER
Keywords
PDMS membrane; Curved microstructure; Elasticity of PDMS; Embryoid body
Citation
BIOMEDICAL MICRODEVICES, v.12, no.1, pp.49 - 54
Indexed
SCIE
SCOPUS
Journal Title
BIOMEDICAL MICRODEVICES
Volume
12
Number
1
Start Page
49
End Page
54
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/117060
DOI
10.1007/s10544-009-9357-x
ISSN
1387-2176
Abstract
In this paper, we propose a method to construct three-dimensional curved microstructures with easy control of the size, position and shape, by exploiting the elasticity of poly(dimethylsiloxane) (PDMS) membranes and basic physics. For this end, we developed the method to handle thin PDMS membrane safely, and to replicate PDMS microstructure from the PDMS mold. Using this method, we demonstrated two potential applications: (1) the use of concave well for the formation of embryoid body (EB) to differentiate into neuronal cells, and (2) the fabrication of SU-8 and hydrogel microparticles having diverse curved shapes. The curved structures were successfully fabricated with simple process, and EBs were formed in the concave well and differentiated into the neuronal cells. Microparticles with diverse shapes were fabricated from a range of materials for potential use as drug carrier and pH responsive micro-actuator elements.
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Graduate School > Department of Bioengineering > 1. Journal Articles
College of Health Sciences > School of Biomedical Engineering > 1. Journal Articles

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