Albumin mediates PPAR-gamma or C/EBP-alpha-induced phenotypic changes in pancreatic stellate cells
DC Field | Value | Language |
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dc.contributor.author | Kim, Nayoung | - |
dc.contributor.author | Choi, Soyoung | - |
dc.contributor.author | Lim, Chaeseung | - |
dc.contributor.author | Lee, Hongsik | - |
dc.contributor.author | Oh, Junseo | - |
dc.date.accessioned | 2021-09-08T05:50:24Z | - |
dc.date.available | 2021-09-08T05:50:24Z | - |
dc.date.created | 2021-06-11 | - |
dc.date.issued | 2010-01-01 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/117176 | - |
dc.description.abstract | Activation of quiescent hepatic stellate cells (HSCs) into myofibroblast-like cells is a key event of liver fibrosis. and adipogenic transcription factors, PPAR-gamma and C/EBP-alpha, reverse HSC activation. As albumin was reported to maintain the quiescent phenotype of stellate cells, we examined whether it plays a role in PPAR-gamma and C/EBP-alpha-mediated effects. Pancreatic stellate cells (PSCs) were isolated from rat pancreas and used in their culture-activated phenotype. Forced expression of PPAR-gamma or C/EBP-alpha in PSCs increased albumin mRNA and protein levels by >2 5-fold, which is accompanied with increased C/EBP-beta binding to albumin promoter. PPAR-gamma and C/EBP-alpha also induced a phenotypic switch from activated to quiescent cells and. interestingly, suppression of albumin using short-hairpin RNA (shRNA) blocked their effects Therefore. our findings suggest that albumin may be a downstream effector of PPAR-gamma and C/EBP-alpha in PSCs and that it can be an attractive molecular target for anti-fibrotic therapies. (C) 2009 Elsevier Inc All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | IN-VIVO | - |
dc.subject | ACTIVATION | - |
dc.subject | GENE | - |
dc.subject | IDENTIFICATION | - |
dc.subject | MECHANISMS | - |
dc.subject | CULTURE | - |
dc.subject | TARGET | - |
dc.subject | LIVER | - |
dc.title | Albumin mediates PPAR-gamma or C/EBP-alpha-induced phenotypic changes in pancreatic stellate cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Hongsik | - |
dc.contributor.affiliatedAuthor | Oh, Junseo | - |
dc.identifier.doi | 10.1016/j.bbrc.2009.11.112 | - |
dc.identifier.scopusid | 2-s2.0-72949104130 | - |
dc.identifier.wosid | 000273624500112 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.391, no.1, pp.640 - 644 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 391 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 640 | - |
dc.citation.endPage | 644 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | CULTURE | - |
dc.subject.keywordPlus | TARGET | - |
dc.subject.keywordPlus | LIVER | - |
dc.subject.keywordAuthor | Albumin | - |
dc.subject.keywordAuthor | Pancreatic stellate cells | - |
dc.subject.keywordAuthor | Lipid droplet formation | - |
dc.subject.keywordAuthor | Fibrosis | - |
dc.subject.keywordAuthor | PPAR-gamma | - |
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