ICAM-3 enhances the migratory and invasive potential of human non-small cell lung cancer cells by inducing MMP-2 and MMP-9 via Akt and CREB
DC Field | Value | Language |
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dc.contributor.author | Park, Jong Kuk | - |
dc.contributor.author | Park, Seon Ho | - |
dc.contributor.author | So, Kwangsup | - |
dc.contributor.author | Bae, In Hwa | - |
dc.contributor.author | Yoo, Young Do | - |
dc.contributor.author | Um, Hong-Duck | - |
dc.date.accessioned | 2021-09-08T06:08:20Z | - |
dc.date.available | 2021-09-08T06:08:20Z | - |
dc.date.created | 2021-06-11 | - |
dc.date.issued | 2010-01 | - |
dc.identifier.issn | 1019-6439 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/117270 | - |
dc.description.abstract | We have previously reported that intercellular adhesion molecule-3 (ICAM-3) is associated with ail increase of cellular radio-resistance and cancer cell proliferation. In this study, we hypothesized that ICAM-3 has an additional effect on cancer cell migration and invasion because molecules induced by ICAM-3 are known its regulators of cell migration and invasion. To examine this hypothesis, we used NCI-H1299 non-small cell lung cancer (NSCLC) cell line (p53 and PTEN null cell) and constructed an ICAM-3-over-expressing stable transfectant, which exhibited increased cell migration and invasion. The increased migration and invasion resulted from Up-regulation of expression and activities of MMP-2 and MMP-9. ICAM-3 also increased Akt phosphorylation, which caused an increase in cellular migration/invasion and MMP activities. Activity of several transcriptional factors located downstream in the Akt pathway was also tested, and constitutive activation of adenosine 3', 5'-monophosphate response element-binding protein (CREB) by ICAM-3 was detected. Blockage of the Akt pathway attenuated CREB activation, and a decrease in CREB expression reduced cellular migration/invasion and activity of MMPs. This result indicates that CREB functions in the signaling pathway between Akt and MMP. We also showed ICAM-3-induced cell migration and invasion in NCI-H460 NSCLC cells (wild-type p53 and PTEN cell) through the same signaling pathway. Taken together, our findings suggest that ICAM-3 stimulates cancer cell migration/invasion via ICAM-3/Akt/CREB/MMP pathway regardless of p53 and PTEN status, and this reflects the possibility that ICAM-3 could be considered as a candidate for anti-cancer drug development and as a cancer diagnostic marker. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPANDIDOS PUBL LTD | - |
dc.subject | FOCAL ADHESION KINASE | - |
dc.subject | MATRIX METALLOPROTEINASE-2 | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | TUMOR-GROWTH | - |
dc.subject | MOLECULES | - |
dc.subject | METASTASIS | - |
dc.subject | MELANOMA | - |
dc.subject | PATHWAY | - |
dc.subject | P53 | - |
dc.subject | INHIBITION | - |
dc.title | ICAM-3 enhances the migratory and invasive potential of human non-small cell lung cancer cells by inducing MMP-2 and MMP-9 via Akt and CREB | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoo, Young Do | - |
dc.identifier.doi | 10.3892/ijo_00000489 | - |
dc.identifier.scopusid | 2-s2.0-74549132674 | - |
dc.identifier.wosid | 000272877100020 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF ONCOLOGY, v.36, no.1, pp.181 - 192 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF ONCOLOGY | - |
dc.citation.title | INTERNATIONAL JOURNAL OF ONCOLOGY | - |
dc.citation.volume | 36 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 181 | - |
dc.citation.endPage | 192 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | FOCAL ADHESION KINASE | - |
dc.subject.keywordPlus | MATRIX METALLOPROTEINASE-2 | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | TUMOR-GROWTH | - |
dc.subject.keywordPlus | MOLECULES | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | MELANOMA | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | P53 | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordAuthor | ICAM-3 | - |
dc.subject.keywordAuthor | migration | - |
dc.subject.keywordAuthor | invasion | - |
dc.subject.keywordAuthor | Akt | - |
dc.subject.keywordAuthor | CREB | - |
dc.subject.keywordAuthor | MMP | - |
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