Catechol-O-methyltransferase Val158Met polymorphism affects therapeutic response to mood stabilizer in symptomatic manic patients
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Hwa-Young | - |
dc.contributor.author | Kim, Yong-Ku | - |
dc.date.accessioned | 2021-09-08T06:13:57Z | - |
dc.date.available | 2021-09-08T06:13:57Z | - |
dc.date.created | 2021-06-11 | - |
dc.date.issued | 2010-01 | - |
dc.identifier.issn | 0165-1781 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/117302 | - |
dc.description.abstract | Catechol-O-methyltransferase (COMT) is a candidate gene for the pathogenesis of some psychiatric disorders. The aim of this study is to examine the role of the COMT gene Val158Met polymorphism on the clinical aspects of bipolar disorder including symptomatology and therapeutic response. This study comprised 144 unrelated manic patients who met strict DSM-IV criteria for bipolar I disorder and 157 healthy unrelated controls. All subjects were of Korean ethnicity. To evaluate the clinical symptoms, we used the Young Mania Rating Scale at baseline and 6 weeks after treatment. No statistically significant difference in genotype distribution was found between manic patients and normal controls. There was also no significant difference in symptornatology among the genotypes in manic patients. In therapeutic response, however, patients with the Met/Met genotype were significantly more frequent in the non-responder than in the responder group. Our results suggest that the COMT gene polymorphism in the therapeutic response to mood stabilizers in manic patients. Further studies with a larger number of subjects and well-controlled design will be required to better understand the role of the COMT gene polymorphism on the therapeutic response to mood stabilizer in manic patients. (C) 2008 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.subject | LOW-ACTIVITY ALLELE | - |
dc.subject | FAMILY-BASED ASSOCIATION | - |
dc.subject | BIPOLAR DISORDER | - |
dc.subject | FUNCTIONAL POLYMORPHISM | - |
dc.subject | METHYL-TRANSFERASE | - |
dc.subject | GENE POLYMORPHISM | - |
dc.subject | COMT GENE | - |
dc.subject | METABOLITES | - |
dc.subject | GENOTYPE | - |
dc.subject | PHARMACOGENETICS | - |
dc.title | Catechol-O-methyltransferase Val158Met polymorphism affects therapeutic response to mood stabilizer in symptomatic manic patients | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yong-Ku | - |
dc.identifier.doi | 10.1016/j.psychres.2008.09.011 | - |
dc.identifier.scopusid | 2-s2.0-72049128051 | - |
dc.identifier.wosid | 000274374800012 | - |
dc.identifier.bibliographicCitation | PSYCHIATRY RESEARCH, v.175, no.1-2, pp.63 - 66 | - |
dc.relation.isPartOf | PSYCHIATRY RESEARCH | - |
dc.citation.title | PSYCHIATRY RESEARCH | - |
dc.citation.volume | 175 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 63 | - |
dc.citation.endPage | 66 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | ssci | - |
dc.description.journalRegisteredClass | ahci | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.subject.keywordPlus | LOW-ACTIVITY ALLELE | - |
dc.subject.keywordPlus | FAMILY-BASED ASSOCIATION | - |
dc.subject.keywordPlus | BIPOLAR DISORDER | - |
dc.subject.keywordPlus | FUNCTIONAL POLYMORPHISM | - |
dc.subject.keywordPlus | METHYL-TRANSFERASE | - |
dc.subject.keywordPlus | GENE POLYMORPHISM | - |
dc.subject.keywordPlus | COMT GENE | - |
dc.subject.keywordPlus | METABOLITES | - |
dc.subject.keywordPlus | GENOTYPE | - |
dc.subject.keywordPlus | PHARMACOGENETICS | - |
dc.subject.keywordAuthor | Manic patients | - |
dc.subject.keywordAuthor | Catechol-O-methyltransferase (COMT) | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Therapeutic response | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.