Identification of Differentially Expressed Genes in Human Mesenchymal Stem Cell-Derived Neurons
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ji Hye Heo | - |
dc.contributor.author | 조경진 | - |
dc.contributor.author | 최달웅 | - |
dc.contributor.author | 김성욱 | - |
dc.date.accessioned | 2021-09-08T07:06:31Z | - |
dc.date.available | 2021-09-08T07:06:31Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1976-8257 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/117587 | - |
dc.description.abstract | Mesenchymal stem cells (MSCs) have greater potential for immediate clinical and toxicological applications,due to their ability to self-renew, proliferate, and differentiate into a variety of cell types. To identify novel candidate genes that were specifically expressed during transdifferentiation of human MSCs to neuronal cells, we performed a differential expression analysis with random priming approach using annealing control primer-based differential display reverse transcription-polymerase chain reaction approach. We identified genes for acyl-CoA thioesterase, tissue inhibitor of metalloproteinases-1, brain glycogen phosphorylase,ubiquitin C-terminal hydrolase and aldehyde reductase were up-regualted, whereas genes for transgelin and heparan sulfate proteoglycan were down-regulated in MSC-derived neurons. These differentially expressed genes may have potential role in regulation of neurogenesis. This study could be applied to environmental toxicology in the field of testing the toxicity of a chemical or a physical agent. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | 한국독성학회 | - |
dc.title | Identification of Differentially Expressed Genes in Human Mesenchymal Stem Cell-Derived Neurons | - |
dc.title.alternative | Identification of Differentially Expressed Genes in Human Mesenchymal Stem Cell-Derived Neurons | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 조경진 | - |
dc.contributor.affiliatedAuthor | 최달웅 | - |
dc.contributor.affiliatedAuthor | 김성욱 | - |
dc.identifier.bibliographicCitation | 한국독성학회지, v.26, no.1, pp.15 - 19 | - |
dc.relation.isPartOf | 한국독성학회지 | - |
dc.citation.title | 한국독성학회지 | - |
dc.citation.volume | 26 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 15 | - |
dc.citation.endPage | 19 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART001425080 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Mesenchymal stem cells | - |
dc.subject.keywordAuthor | Neuron | - |
dc.subject.keywordAuthor | Differentially expressed genes | - |
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