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Synthesis and In Vitro Cytotoxic Activities of 2-Alkyl-2,3-dihydro-1H- 2,6-diazacyclopenta[b]anthracene-5,10-diones
Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | 곽재환 | - |
| dc.contributor.author | Kwon Namgoong | - |
| dc.contributor.author | 정재경 | - |
| dc.contributor.author | 한상배 | - |
| dc.contributor.author | 조정숙 | - |
| dc.contributor.author | 김환묵 | - |
| dc.contributor.author | 박성규 | - |
| dc.contributor.author | 이기호 | - |
| dc.contributor.author | 강종순 | - |
| dc.contributor.author | 이희순 | - |
| dc.date.accessioned | 2021-09-08T07:58:22Z | - |
| dc.date.available | 2021-09-08T07:58:22Z | - |
| dc.date.created | 2021-06-17 | - |
| dc.date.issued | 2010 | - |
| dc.identifier.issn | 0253-6269 | - |
| dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/117880 | - |
| dc.description.abstract | A series of 2-alkyl-2,3-dihydro-1H-2,6-diazacyclopenta[b]anthracene-5,10-diones (4a-f) was synthesized and their in vitro cytotoxic activities were evaluated against six human cancer cell lines (HCT15, SK-OV-3, SNB19, A549, MCF7 and MCF7/ADR). They all appeared to be less potent than doxorubicin against all doxorubicin sensitive human cancer cell lines tested. However, these compounds retained considerable cytotoxic activity against the doxorubicinresistant cell line MCF7/ADR, implying their therapeutic potential to treat doxorubicin-resistant tumors. The most active compound 4c was equipotent with doxorubicin against HCT15 cell line. | - |
| dc.language | English | - |
| dc.language.iso | en | - |
| dc.publisher | 대한약학회 | - |
| dc.title | Synthesis and In Vitro Cytotoxic Activities of 2-Alkyl-2,3-dihydro-1H- 2,6-diazacyclopenta[b]anthracene-5,10-diones | - |
| dc.title.alternative | Synthesis and In Vitro Cytotoxic Activities of 2-Alkyl-2,3-dihydro-1H- 2,6-diazacyclopenta[b]anthracene-5,10-diones | - |
| dc.type | Article | - |
| dc.contributor.affiliatedAuthor | 김환묵 | - |
| dc.contributor.affiliatedAuthor | 박성규 | - |
| dc.contributor.affiliatedAuthor | 이기호 | - |
| dc.identifier.bibliographicCitation | Archives of Pharmacal Research, v.33, no.5, pp.663 - 667 | - |
| dc.relation.isPartOf | Archives of Pharmacal Research | - |
| dc.citation.title | Archives of Pharmacal Research | - |
| dc.citation.volume | 33 | - |
| dc.citation.number | 5 | - |
| dc.citation.startPage | 663 | - |
| dc.citation.endPage | 667 | - |
| dc.type.rims | ART | - |
| dc.identifier.kciid | ART001445271 | - |
| dc.description.journalClass | 1 | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.description.journalRegisteredClass | kci | - |
| dc.subject.keywordAuthor | Cytotoxic activity | - |
| dc.subject.keywordAuthor | Diazacyclopenta[b]anthracene-5 | - |
| dc.subject.keywordAuthor | 10-diones | - |
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Related Researcher
- Lee, Ki ho
- College of Pharmacy (Department of Pharmaceutical Science)