The role of transglutaminase-2 in fibroproliferation after lipopolysaccharide-induced acute lung injury
DC Field | Value | Language |
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dc.contributor.author | Kim, J.H. | - |
dc.date.accessioned | 2021-09-08T09:02:38Z | - |
dc.date.available | 2021-09-08T09:02:38Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1738-3536 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/118254 | - |
dc.description.abstract | Background: Transglutaminase-2 (TG-2) has been reported to play an important role in the process of fibrosis. However, TG-2 studies on fibroproliferation of acute lung injury (ALI) are absent. The purpose of this study was to investigate the role of TG-2 in the fibroproliferation of lipopolysaccharide (LPS)-induced ALI. Methods: The male C57BL/6 mice of 5 weeks age were divided into 3 groups; control group (n=30) in which 50 μL of saline was given intratracheally (IT), LPS group (n=30) in which LPS 0.5 mg/kg/50 μL of saline was given IT, and LPS+Cyst group treated with intraperitoneal 200 mg/kg of cystamine, competitive inhibitor of TG-2, after induction of ALI by LPS. TG-2 activity and nuclear factor (NF)-κB were measured in lung tissue homogenate. Tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, myeloperoxidase (MPO), and transforming growth factor (TGF)-β1 were measured using bronchoalveolar lavage fluids. Histopathologic ALI score and Mallory's phosphotunisticacid hematoxylin (PTAH) for collagen and fibronectin deposition were performed.Results: The TG-2 activities in the LPS group were significantly higher than the control and LPS+Cyst groups(p<0.05). The TNF-α and IL-1β concentrations and NF-κB activity were lower in the LPS+Cyst group than theLPS group (p<0.05). The LPS+Cyst group showed lower MPO, ALI score, TGF-β1 concentration, and Mallory'sPTAH stain than the LPS group, but the differences were not significant (p>0.05).Conclusion: Inhibition of TG-2 activity in the LPS-induced ALI prevented early inflammatory parameters, but hadlimited effects on late ALI and fibroproliferative parameters. Copyright©2010. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved. | - |
dc.language | Korean | - |
dc.language.iso | ko | - |
dc.subject | collagen | - |
dc.subject | cystamine | - |
dc.subject | fibronectin | - |
dc.subject | hematoxylin | - |
dc.subject | immunoglobulin enhancer binding protein | - |
dc.subject | interleukin 1beta | - |
dc.subject | interleukin 6 | - |
dc.subject | lipopolysaccharide | - |
dc.subject | myeloperoxidase | - |
dc.subject | phosphotunistic acid hematoxylin | - |
dc.subject | protein glutamine gamma glutamyltransferase 2 | - |
dc.subject | transforming growth factor beta1 | - |
dc.subject | tumor necrosis factor alpha | - |
dc.subject | unclassified drug | - |
dc.subject | acute lung injury | - |
dc.subject | animal experiment | - |
dc.subject | animal model | - |
dc.subject | animal tissue | - |
dc.subject | article | - |
dc.subject | cell proliferation | - |
dc.subject | concentration (parameters) | - |
dc.subject | controlled study | - |
dc.subject | histopathology | - |
dc.subject | lung lavage | - |
dc.subject | lung parenchyma | - |
dc.subject | male | - |
dc.subject | mouse | - |
dc.subject | nonhuman | - |
dc.subject | scoring system | - |
dc.title | The role of transglutaminase-2 in fibroproliferation after lipopolysaccharide-induced acute lung injury | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, J.H. | - |
dc.identifier.doi | 10.4046/trd.2010.69.5.337 | - |
dc.identifier.scopusid | 2-s2.0-81255209172 | - |
dc.identifier.bibliographicCitation | Tuberculosis and Respiratory Diseases, v.69, no.5, pp.337 - 347 | - |
dc.relation.isPartOf | Tuberculosis and Respiratory Diseases | - |
dc.citation.title | Tuberculosis and Respiratory Diseases | - |
dc.citation.volume | 69 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 337 | - |
dc.citation.endPage | 347 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001498522 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordPlus | collagen | - |
dc.subject.keywordPlus | cystamine | - |
dc.subject.keywordPlus | fibronectin | - |
dc.subject.keywordPlus | hematoxylin | - |
dc.subject.keywordPlus | immunoglobulin enhancer binding protein | - |
dc.subject.keywordPlus | interleukin 1beta | - |
dc.subject.keywordPlus | interleukin 6 | - |
dc.subject.keywordPlus | lipopolysaccharide | - |
dc.subject.keywordPlus | myeloperoxidase | - |
dc.subject.keywordPlus | phosphotunistic acid hematoxylin | - |
dc.subject.keywordPlus | protein glutamine gamma glutamyltransferase 2 | - |
dc.subject.keywordPlus | transforming growth factor beta1 | - |
dc.subject.keywordPlus | tumor necrosis factor alpha | - |
dc.subject.keywordPlus | unclassified drug | - |
dc.subject.keywordPlus | acute lung injury | - |
dc.subject.keywordPlus | animal experiment | - |
dc.subject.keywordPlus | animal model | - |
dc.subject.keywordPlus | animal tissue | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | cell proliferation | - |
dc.subject.keywordPlus | concentration (parameters) | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | histopathology | - |
dc.subject.keywordPlus | lung lavage | - |
dc.subject.keywordPlus | lung parenchyma | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | mouse | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | scoring system | - |
dc.subject.keywordAuthor | Acute lung injury | - |
dc.subject.keywordAuthor | Fibrosis | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Lipopolysaccharides | - |
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