Activation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injury
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bajwa, A. | - |
dc.contributor.author | Jo, S.-K. | - |
dc.contributor.author | Ye, H. | - |
dc.contributor.author | Huang, L. | - |
dc.contributor.author | Dondeti, K.R. | - |
dc.contributor.author | Rosin, D.L. | - |
dc.contributor.author | Haase, V.H. | - |
dc.contributor.author | Macdonald, T.L. | - |
dc.contributor.author | Lynch, K.R. | - |
dc.contributor.author | Okusa, M.D. | - |
dc.date.accessioned | 2021-09-08T09:06:23Z | - |
dc.date.available | 2021-09-08T09:06:23Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1046-6673 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/118273 | - |
dc.description.abstract | Agonists of the sphingosine-1-phosphate receptor (S1PR) attenuate kidney ischemia-reperfusion injury (IRI). Previous studies suggested that S1P 1R-induced lymphopenia mediates this protective effect, but lymphocyte-independent mechanisms could also contribute. Here, we investigated the effects of S1PR agonists on kidney IRI in mice that lack T and B lymphocytes (Rag-1 knockout mice). Administration of the nonselective S1PR agonist FTY720 or the selective S1P1R agonist SEW2871 reduced injury in both Rag-1 knockout and wild-type mice. In vitro, SEW2871 significantly attenuated LPS- or hypoxia/reoxygenation-induced apoptosis in cultured mouse proximal tubule epithelial cells, supporting a direct protective effect of S1P1R agonists via mitogen-activated protein kinase and/or Akt pathways. S1P 1Rs in the proximal tubule mediated IRI in vivo as well: Mice deficient in proximal tubule S1P1Rs experienced a greater decline in renal function after IRI than control mice and their kidneys were no longer protected by SEW2871 administration. In summary, S1PRs in the proximal tubule are necessary for stress-induced cell survival, and S1P1R agonists are renoprotective via direct effects on the tubule cells. Selective agonists of S1P1Rs may hold therapeutic potential for the prevention and treatment of acute kidney injury. Copyright © 2010 by the American Society of Nephrology. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.subject | 5 (4 phenyl 5 trifluoromethyl 2 thienyl) 3 (3 trifluoromethylphenyl) 1,2,4 oxadiazole | - |
dc.subject | fingolimod | - |
dc.subject | mitogen activated protein kinase | - |
dc.subject | protein kinase B | - |
dc.subject | sphingosine 1 phosphate receptor | - |
dc.subject | animal cell | - |
dc.subject | animal experiment | - |
dc.subject | animal model | - |
dc.subject | apoptosis | - |
dc.subject | article | - |
dc.subject | cell infiltration | - |
dc.subject | cell survival | - |
dc.subject | controlled study | - |
dc.subject | creatinine blood level | - |
dc.subject | enzyme activation | - |
dc.subject | kidney function | - |
dc.subject | kidney injury | - |
dc.subject | kidney ischemia | - |
dc.subject | kidney proximal tubule | - |
dc.subject | lymphocytopenia | - |
dc.subject | male | - |
dc.subject | mouse | - |
dc.subject | nonhuman | - |
dc.subject | priority journal | - |
dc.subject | reperfusion injury | - |
dc.subject | Animals | - |
dc.subject | Apoptosis | - |
dc.subject | Cell Movement | - |
dc.subject | Disease Models, Animal | - |
dc.subject | Epithelial Cells | - |
dc.subject | Homeodomain Proteins | - |
dc.subject | Kidney Failure, Acute | - |
dc.subject | Kidney Tubules, Proximal | - |
dc.subject | Leukocytes | - |
dc.subject | Lipopolysaccharides | - |
dc.subject | Mice | - |
dc.subject | Mice, Knockout | - |
dc.subject | Mitogen-Activated Protein Kinase Kinases | - |
dc.subject | Oxadiazoles | - |
dc.subject | Propylene Glycols | - |
dc.subject | Receptors, Lysosphingolipid | - |
dc.subject | Reperfusion Injury | - |
dc.subject | RNA, Messenger | - |
dc.subject | Signal Transduction | - |
dc.subject | Sphingosine | - |
dc.subject | Thiophenes | - |
dc.title | Activation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injury | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jo, S.-K. | - |
dc.identifier.doi | 10.1681/ASN.2009060662 | - |
dc.identifier.scopusid | 2-s2.0-77952985501 | - |
dc.identifier.bibliographicCitation | Journal of the American Society of Nephrology, v.21, no.6, pp.955 - 965 | - |
dc.relation.isPartOf | Journal of the American Society of Nephrology | - |
dc.citation.title | Journal of the American Society of Nephrology | - |
dc.citation.volume | 21 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 955 | - |
dc.citation.endPage | 965 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | 5 (4 phenyl 5 trifluoromethyl 2 thienyl) 3 (3 trifluoromethylphenyl) 1,2,4 oxadiazole | - |
dc.subject.keywordPlus | fingolimod | - |
dc.subject.keywordPlus | mitogen activated protein kinase | - |
dc.subject.keywordPlus | protein kinase B | - |
dc.subject.keywordPlus | sphingosine 1 phosphate receptor | - |
dc.subject.keywordPlus | animal cell | - |
dc.subject.keywordPlus | animal experiment | - |
dc.subject.keywordPlus | animal model | - |
dc.subject.keywordPlus | apoptosis | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | cell infiltration | - |
dc.subject.keywordPlus | cell survival | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | creatinine blood level | - |
dc.subject.keywordPlus | enzyme activation | - |
dc.subject.keywordPlus | kidney function | - |
dc.subject.keywordPlus | kidney injury | - |
dc.subject.keywordPlus | kidney ischemia | - |
dc.subject.keywordPlus | kidney proximal tubule | - |
dc.subject.keywordPlus | lymphocytopenia | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | mouse | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | reperfusion injury | - |
dc.subject.keywordPlus | Animals | - |
dc.subject.keywordPlus | Apoptosis | - |
dc.subject.keywordPlus | Cell Movement | - |
dc.subject.keywordPlus | Disease Models, Animal | - |
dc.subject.keywordPlus | Epithelial Cells | - |
dc.subject.keywordPlus | Homeodomain Proteins | - |
dc.subject.keywordPlus | Kidney Failure, Acute | - |
dc.subject.keywordPlus | Kidney Tubules, Proximal | - |
dc.subject.keywordPlus | Leukocytes | - |
dc.subject.keywordPlus | Lipopolysaccharides | - |
dc.subject.keywordPlus | Mice | - |
dc.subject.keywordPlus | Mice, Knockout | - |
dc.subject.keywordPlus | Mitogen-Activated Protein Kinase Kinases | - |
dc.subject.keywordPlus | Oxadiazoles | - |
dc.subject.keywordPlus | Propylene Glycols | - |
dc.subject.keywordPlus | Receptors, Lysosphingolipid | - |
dc.subject.keywordPlus | Reperfusion Injury | - |
dc.subject.keywordPlus | RNA, Messenger | - |
dc.subject.keywordPlus | Signal Transduction | - |
dc.subject.keywordPlus | Sphingosine | - |
dc.subject.keywordPlus | Thiophenes | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.