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The Biological Monitoring of Urinary 1-hydroxypyrene by PAH Exposure Among Smokers

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dc.contributor.authorLee, K. H.-
dc.contributor.authorByeon, S. H.-
dc.date.accessioned2021-09-08T09:52:10Z-
dc.date.available2021-09-08T09:52:10Z-
dc.date.issued2010-
dc.identifier.issn1735-6865-
dc.identifier.issn2008-2304-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/118508-
dc.description.abstractThis study examines changes in the urinary 1-hydroxypyrene (1-OHP) concentration as a polycyclic aromatic hydrocarbon (PAH) metabolite related to smoking among eight volunteers. The study subjects consisted of 8 participants (2 smokers, 4 ex-smokers and 2 non-smokers; mean age 23, range 21 24 years old) in a smoking cessation program. Three urine samples were collected each week for 4 weeks from each participant to give a total of 96 urine samples. None of the participants smoked during the study period. Levels of urinary 1-OHP, as an internal dose marker of smoke containing PAHs, were measured by high performance liquid chromatography (HPLC) fluorescence detector. Urinary 1-OHP levels in the ex-smokers were decreased during the 4 weeks study period, due to ambient sources of PAH exposure. Thus, smoking cessation was only expected to result in reduction of urinary 1-OHP. Urinary 1-OHP levels were significantly correlated with the amounts of cigarettes smoked, as assessed by the questionnaire (Spearman's correlation coefficient, r=0.23, P=0.03). This study suggested that urinary 1-OHP can be a potentially useful biomarker of smoke.-
dc.format.extent4-
dc.language영어-
dc.language.isoENG-
dc.publisherSPRINGER INTERNATIONAL PUBLISHING AG-
dc.titleThe Biological Monitoring of Urinary 1-hydroxypyrene by PAH Exposure Among Smokers-
dc.typeArticle-
dc.publisher.location스위스-
dc.identifier.scopusid2-s2.0-77955495913-
dc.identifier.wosid000279971400008-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH, v.4, no.3, pp 439 - 442-
dc.citation.titleINTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH-
dc.citation.volume4-
dc.citation.number3-
dc.citation.startPage439-
dc.citation.endPage442-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaEnvironmental Sciences & Ecology-
dc.relation.journalWebOfScienceCategoryEnvironmental Sciences-
dc.subject.keywordPlusPOLYCYCLIC AROMATIC-HYDROCARBONS-
dc.subject.keywordPlusCIGARETTE-SMOKING-
dc.subject.keywordPlusLUNG-CANCER-
dc.subject.keywordPlusBIOMARKER-
dc.subject.keywordPlusCARCINOGEN-
dc.subject.keywordPlusWORKERS-
dc.subject.keywordAuthorBiomarker-
dc.subject.keywordAuthorPolycyclic aromatic hydrocarbons-
dc.subject.keywordAuthor1-hydroxypyrene-
dc.subject.keywordAuthorCigarette smoking-
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