Electrically-driven hydrogel actuators in microfluidic channels: fabrication, characterization, and biological application
- Authors
- Kwon, Gu Han; Choi, Yoon Young; Park, Joong Yull; Woo, Dong Hun; Lee, Kyu Back; Kim, Jong Hoon; Lee, Sang-Hoon
- Issue Date
- 2010
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- LAB ON A CHIP, v.10, no.12, pp.1604 - 1610
- Indexed
- SCIE
SCOPUS
- Journal Title
- LAB ON A CHIP
- Volume
- 10
- Number
- 12
- Start Page
- 1604
- End Page
- 1610
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/118518
- DOI
- 10.1039/b926443d
- ISSN
- 1473-0197
- Abstract
- The utility of electro-responsive smart materials has been limited by bubble generation (hydrolysis) during application of electrical fields and by biocompatibility issues. Here we describe the design of a device that overcomes these limitations by combining material properties, new design concepts, and microtechnology. 4-Hydroxybutyl acrylate (4-HBA) was used as a backbone hydrogel material, and its actuating behavior, bending force, and elasticity were extensively characterized as a function of size and acrylic acid concentration. To prevent bubble generation, the system was designed such that the hydrogel actuator could be operated at low driving voltages (<1.2 V). A microfluidic channel with an integrated electroactive hydrogel actuator was developed for sorting particles. This device could be operated in cell culture media, and the sorting capabilities were initially assessed by sorting droplets in an oil droplet emulsion. Biocompatibility was subsequently tested by sorting mouse embryoid bodies (mEBs) according to size. The sorted and collected mEBs maintained pluripotency, and selected mEBs successfully differentiated into three germ layers: endoderm, mesoderm, and ectoderm. The electroactive hydrogel device, integrated into a microfluidic system, successfully demonstrated the practical application of smart materials for use in cell biology.
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Collections - College of Health Sciences > School of Biomedical Engineering > 1. Journal Articles
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