Efficacy and Safety of Micafungin as an Empirical Antifungal Agent for Febrile Neutropenic Patients with Hematological Diseases
- Authors
- Park, Joon Seong; Kim, Dong Hwan; Choi, Chul Won; Jeong, Seong Hyun; Choi, Jin-Hyuk; Kim, Kihyun; Kim, Seok Jin; Jung, Chul Won; Yang, Deok-Hwan; Jang, Jun Ho
- Issue Date
- 2010
- Publisher
- KARGER
- Keywords
- Hematological diseases; Micafungin; Neutropenic fever
- Citation
- ACTA HAEMATOLOGICA, v.124, no.2, pp.92 - 97
- Indexed
- SCIE
SCOPUS
- Journal Title
- ACTA HAEMATOLOGICA
- Volume
- 124
- Number
- 2
- Start Page
- 92
- End Page
- 97
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/118520
- DOI
- 10.1159/000315558
- ISSN
- 0001-5792
- Abstract
- Background: This observational study was conducted to document the efficacy and safety of the use of micafungin (Mycamine) as an empirical antifungal agent in febrile neutropenic patients. Methods: Micafungin was administered for sustained fever (> 38.4 degrees C) on days 3-5 following the initiation of empirical antibiotic therapy. The overall success rate and side effects were evaluated. Results: A total of 47 patients with acute myeloid leukemia, acute lymphoblastic leukemia, myelodysplastic syndrome and lymphoma were enrolled in the study. The overall success rate of micafungin was 61.7% (29/47). A total of 3 patients (6.4%) experienced grade 3/4 elevations in their aspartate aminotransferase levels, and 10 patients (21%) experienced grade 3/4 hyperbilirubinemia, 9 of which resolved. Four patients died of septic shock. Younger patients (! 50 years) and patients with acute lymphoblastic leukemia exhibited a better response to micafungin than other patients. Patients that were less profoundly neutropenic (>= 0.05 x 10(9)/l) also had a better response to micafungin, as did the patients who recovered from their fever or neutropenia. Conclusion: Micafungin has an excellent efficacy (61.7%) and safety profile when used as an empirical antifungal agent in febrile neutropenic patients with hematological disorders. Copyright (c) 2010 S. Karger AG, Basel
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