Toll-Like Receptor-9 Agonist Inhibits Airway Inflammation, Remodeling and Hyperreactivity in Mice Exposed to Chronic Environmental Tobacco Smoke and Allergen
DC Field | Value | Language |
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dc.contributor.author | Song, Dae Jin | - |
dc.contributor.author | Min, Myung Goo | - |
dc.contributor.author | Miller, Marina | - |
dc.contributor.author | Cho, Jae Youn | - |
dc.contributor.author | Yum, Hye Yung | - |
dc.contributor.author | Broide, David H. | - |
dc.date.accessioned | 2021-09-08T09:58:46Z | - |
dc.date.available | 2021-09-08T09:58:46Z | - |
dc.date.created | 2021-06-11 | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1018-2438 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/118545 | - |
dc.description.abstract | Background: As passive environmental tobacco smoke (ETS) exposure in nonsmokers can increase both asthma symptoms and the frequency of asthma exacerbations, we utilized a mouse model, in which ovalbumin (OVA) + ETS induce significantly increased levels of eosinophilic airway inflammation and remodeling compared to either stimulus alone, to determine whether a Toll-like receptor-9 (TLR-9) agonist could reduce levels of airway inflammation, airway remodeling and airway hyperreactivity (AHR). Methods: Mice treated with or without a TLR-9 agonist were sensitized to OVA and challenged with OVA + ETS for 1 month. AHR to methacholine was assessed in intubated and ventilated mice. Lung Th2 cytokines and TGF-beta(1) were measured by ELISA. Lungs were processed for histology and immunohistology to quantify eosinophils, mucus, peribronchial fibrosis and smooth muscle changes using image analysis. Results: Administration of a TLR-9 agonist to mice coexposed to chronic ETS and chronic OVA allergen significantly reduced levels of eosinophilic airway inflammation, mucus production, peribronchial fibrosis, the thickness of the peribronchial smooth muscle lay-er, and AHR. The reduced airway remodeling in mice treated with the TLR-9 agonist was associated with significantly reduced numbers of peribronchial MBP+ and peribronchial TGF-beta(1) + cells, and with significantly reduced levels of lung Th2 cytokines [interleukin-5 and interleukin-13] and TGF-beta(1). Conclusion: These studies demonstrate that TLR-9-based therapies inhibit airway inflammation, remodeling and AHR in mice coexposed to ETS and allergen who exhibit enhanced airway inflammation and remodeling. Copyright (C) 2009 S. Karger AG, Basel | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KARGER | - |
dc.subject | IMMUNOSTIMULATORY DNA-SEQUENCES | - |
dc.subject | CIGARETTE-SMOKING | - |
dc.subject | EOSINOPHILIC INFLAMMATION | - |
dc.subject | HEALTH OUTCOMES | - |
dc.subject | RAGWEED ALLERGY | - |
dc.subject | 2ND-HAND SMOKE | - |
dc.subject | CHRONIC ASTHMA | - |
dc.subject | MILD ASTHMA | - |
dc.subject | MOUSE MODEL | - |
dc.subject | CORTICOSTEROIDS | - |
dc.title | Toll-Like Receptor-9 Agonist Inhibits Airway Inflammation, Remodeling and Hyperreactivity in Mice Exposed to Chronic Environmental Tobacco Smoke and Allergen | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Dae Jin | - |
dc.identifier.doi | 10.1159/000250437 | - |
dc.identifier.scopusid | 2-s2.0-70350149389 | - |
dc.identifier.wosid | 000275350600003 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, v.151, no.4, pp.285 - 296 | - |
dc.relation.isPartOf | INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | - |
dc.citation.title | INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | - |
dc.citation.volume | 151 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 285 | - |
dc.citation.endPage | 296 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Allergy | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Allergy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | IMMUNOSTIMULATORY DNA-SEQUENCES | - |
dc.subject.keywordPlus | CIGARETTE-SMOKING | - |
dc.subject.keywordPlus | EOSINOPHILIC INFLAMMATION | - |
dc.subject.keywordPlus | HEALTH OUTCOMES | - |
dc.subject.keywordPlus | RAGWEED ALLERGY | - |
dc.subject.keywordPlus | 2ND-HAND SMOKE | - |
dc.subject.keywordPlus | CHRONIC ASTHMA | - |
dc.subject.keywordPlus | MILD ASTHMA | - |
dc.subject.keywordPlus | MOUSE MODEL | - |
dc.subject.keywordPlus | CORTICOSTEROIDS | - |
dc.subject.keywordAuthor | Toll-like receptor-9 | - |
dc.subject.keywordAuthor | Airway hyperreactivity | - |
dc.subject.keywordAuthor | Airway inflammation | - |
dc.subject.keywordAuthor | Airway remodeling | - |
dc.subject.keywordAuthor | Eosinophils | - |
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