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SIMPLE DETERMINATION OF ERDOSTEINE IN HUMAN PLASMA USING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY

Authors
Kim, Sung TaePark, Jeong-SookKim, Hyung TaeKim, Chong-Kook
Issue Date
2010
Publisher
TAYLOR & FRANCIS INC
Keywords
bioequivalence; erdosteine; HPLC; UV
Citation
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, v.33, no.13, pp.1319 - 1327
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
Volume
33
Number
13
Start Page
1319
End Page
1327
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/118672
DOI
10.1080/10826076.2010.489019
ISSN
1082-6076
Abstract
A simple and rapid high-performance liquid chromatography (HPLC) method with UV detection (220nm) was developed for the determination of erdosteine in human plasma. The plasma was prepared by deproteination based on treatment with 6.25% trichloroacetic acid (TCA). After the mixture was centrifuged, the supernatant was separated on CAPCELL PACK C18(4.6x250mm) column. The mobile phase consisted of acetonitrile in phosphate-heptane sulfonate buffer at the volume ration of 5:95 (pH 2.0). Citiolone was used as an internal standard. The calibration curve was linear in concentrations of 0.5-8g/mL with correlation coefficient of 0.999. The limit of quantitation (LOQ) was 0.5g/mL. This method was sensitive with reproducibility and specificity and successfully applied to the bioequivalence study of erdosteine (900mg) in healthy subjects.
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