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Salt concentration-induced dehybridisation of DNA-gold nanoparticle conjugate assemblies for diagnostic applications
- Authors
- Oh, Ju-Hwan; Lee, Jae-Seung
- Issue Date
- 2010
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- CHEMICAL COMMUNICATIONS, v.46, no.34, pp.6382 - 6384
- Indexed
- SCIE
SCOPUS
- Journal Title
- CHEMICAL COMMUNICATIONS
- Volume
- 46
- Number
- 34
- Start Page
- 6382
- End Page
- 6384
- ISSN
- 1359-7345
- Abstract
- We present the cooperative dehybridisation of DNA-gold nanoparticle conjugate (DNA-AuNP) assemblies induced by reduced salt concentration ([salt]), which can be precisely controlled by various conditions. The detection of Ag(+) based upon the [salt]-induced dehybridisation of DNA-AuNP assemblies is five times more sensitive than that achieved under conventional thermal melting conditions.
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