Natural killer T cells promote collagen-induced arthritis in DBA/1 mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, Sundo | - |
dc.contributor.author | Shin, Hyun-suk | - |
dc.contributor.author | Hong, Changwan | - |
dc.contributor.author | Lee, Hyunji | - |
dc.contributor.author | Park, Yoon-Kyung | - |
dc.contributor.author | Shin, Jung Hoon | - |
dc.contributor.author | Hong, Seokmann | - |
dc.contributor.author | Lee, Gap Ryol | - |
dc.contributor.author | Park, Se-Ho | - |
dc.date.accessioned | 2021-09-08T10:38:49Z | - |
dc.date.available | 2021-09-08T10:38:49Z | - |
dc.date.created | 2021-06-11 | - |
dc.date.issued | 2009-12-18 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/118738 | - |
dc.description.abstract | The role of NKT cells in the pathogenesis of collagen-induced arthritis (CIA) remains unclear since most studies have used C57BL/6 (B6) mice, which are less susceptible to CIA than mice with a DBA/1 background. To clarify the immunological functions of NKT cells in CIA, it is necessary to analyze in detail the effects of NKT cell deficiency on CIA development in DBA/1 mice. The incidence and severity of CIA were significantly exacerbated in DBA/1CD1d(+/-) mice as compared to DBA/ICD1d(-/-) mice. In DBA/1CD1d(+/-) mice, antigen-specific responses of B and T cells against CII were remarkably increased and inflammatory cytokine levels were also increased in vivo and in vitro, The number of IL-17-producing NKT cells significantly increased in DBA/1CD1d(+/-) mice as the disease progressed. Our results clearly show that NKT cells are involved not only in accelerating the severity and incidence of CIA but also in perpetuating the disease progression. (C) 2009 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | RHEUMATOID-ARTHRITIS | - |
dc.subject | ALPHA-GALACTOSYLCERAMIDE | - |
dc.subject | NKT CELLS | - |
dc.subject | ACTIVATION | - |
dc.subject | SUSCEPTIBILITY | - |
dc.subject | IMMUNOTHERAPY | - |
dc.subject | AUTOIMMUNITY | - |
dc.subject | LYMPHOCYTES | - |
dc.subject | SUPPRESSION | - |
dc.subject | PATHWAY | - |
dc.title | Natural killer T cells promote collagen-induced arthritis in DBA/1 mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Se-Ho | - |
dc.identifier.doi | 10.1016/j.bbrc.2009.09.008 | - |
dc.identifier.scopusid | 2-s2.0-70449718748 | - |
dc.identifier.wosid | 000272516700010 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.390, no.3, pp.399 - 403 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 390 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 399 | - |
dc.citation.endPage | 403 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | ALPHA-GALACTOSYLCERAMIDE | - |
dc.subject.keywordPlus | NKT CELLS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordPlus | IMMUNOTHERAPY | - |
dc.subject.keywordPlus | AUTOIMMUNITY | - |
dc.subject.keywordPlus | LYMPHOCYTES | - |
dc.subject.keywordPlus | SUPPRESSION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordAuthor | NKT cells | - |
dc.subject.keywordAuthor | CIA | - |
dc.subject.keywordAuthor | Autoimmune disease | - |
dc.subject.keywordAuthor | Th1/Th2 balance | - |
dc.subject.keywordAuthor | IL-17 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.