Blood Eicosapentaenoic Acid and Docosahexaenoic Acid as Predictors of All-Cause Mortality in Patients With Acute Myocardial Infarction - Data From Infarction Prognosis Study (IPS) Registry -
DC Field | Value | Language |
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dc.contributor.author | Lee, Sang-Hak | - |
dc.contributor.author | Shin, Min-Jeong | - |
dc.contributor.author | Kim, Jung-Sun | - |
dc.contributor.author | Ko, Young-Guk | - |
dc.contributor.author | Kang, Seok-Min | - |
dc.contributor.author | Choi, Donghoon | - |
dc.contributor.author | Jang, Yangsoo | - |
dc.contributor.author | Chung, Namsik | - |
dc.contributor.author | Shim, Won-Heum | - |
dc.contributor.author | Cho, Seung-Yun | - |
dc.contributor.author | Manabe, Ichiro | - |
dc.contributor.author | Ha, Jong-Won | - |
dc.date.accessioned | 2021-09-08T10:53:31Z | - |
dc.date.available | 2021-09-08T10:53:31Z | - |
dc.date.created | 2021-06-11 | - |
dc.date.issued | 2009-12 | - |
dc.identifier.issn | 1346-9843 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/118771 | - |
dc.description.abstract | Background: Although omega-3 polyunsaturated fatty acids are known to have beneficial effects on cardiovascular diseases. their prognostic value has not been studied prospectively in patients with acute myocardial infarction (AMI). Methods and Results: The plasma levels of phospholipids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (% of total fatty acids), were measured in 508 patients (365 males;, mean age, 63 years) with AMI. Clinical and biomarker predictors of all-cause and cardiovascular mortality were identified by stepwise Cox regression model. During a mean follow-up of 16.1 months, 36 (7.1%) patients died. After controlling for confounding variables, age (hazard ratio (HR): 1.09, P<0.001), renal insufficiency (HR: 2.84, P=0.01) and EPA level (HR: 0.29 P=0.004) were identified as independent predictors of all cause-mortality. When stratified by gender, age (HR: 1.08, P=0.001) and renal insufficiency (HR: 4.49, P=0.003) were predictors of all-cause-mortality in males, whereas EPA level (HR: 0.18, P=0.009) and angiotensin-converting enzyme inhibitor use (HR: 0.24, P=0.03) were identified as predictive of all-cause-mortality in females. Conclusions: Lower plasma level of EPA, but not DHA, was an independent predictor for all-cause-mortality in patients with AMI, but this relationship was significant only in female patients. (Circ J 2009; 73: 2250-2257) | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | JAPANESE CIRCULATION SOC | - |
dc.subject | N-3 FATTY-ACIDS | - |
dc.subject | FISH CONSUMPTION | - |
dc.subject | CARDIOVASCULAR-DISEASE | - |
dc.subject | CYTOKINE PRODUCTION | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | OMEGA-3 INDEX | - |
dc.subject | RISK | - |
dc.subject | PLASMA | - |
dc.subject | EPA | - |
dc.subject | DHA | - |
dc.title | Blood Eicosapentaenoic Acid and Docosahexaenoic Acid as Predictors of All-Cause Mortality in Patients With Acute Myocardial Infarction - Data From Infarction Prognosis Study (IPS) Registry - | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, Min-Jeong | - |
dc.identifier.doi | 10.1253/circj.CJ-09-0327 | - |
dc.identifier.scopusid | 2-s2.0-73349102791 | - |
dc.identifier.wosid | 000272206900015 | - |
dc.identifier.bibliographicCitation | CIRCULATION JOURNAL, v.73, no.12, pp.2250 - 2257 | - |
dc.relation.isPartOf | CIRCULATION JOURNAL | - |
dc.citation.title | CIRCULATION JOURNAL | - |
dc.citation.volume | 73 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 2250 | - |
dc.citation.endPage | 2257 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.subject.keywordPlus | N-3 FATTY-ACIDS | - |
dc.subject.keywordPlus | FISH CONSUMPTION | - |
dc.subject.keywordPlus | CARDIOVASCULAR-DISEASE | - |
dc.subject.keywordPlus | CYTOKINE PRODUCTION | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | OMEGA-3 INDEX | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | PLASMA | - |
dc.subject.keywordPlus | EPA | - |
dc.subject.keywordPlus | DHA | - |
dc.subject.keywordAuthor | Death | - |
dc.subject.keywordAuthor | Docosahexaenoic acid | - |
dc.subject.keywordAuthor | Eicosapentaenoic acid | - |
dc.subject.keywordAuthor | Myocardial infarction | - |
dc.subject.keywordAuthor | omega-3 fatty acids | - |
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