Effects of protein kinase C delta and phospholipase C-gamma 1 on monocyte chemoattractant protein-1 expression in taxol-induced breast cancer cell death
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Yoon Suk | - |
dc.contributor.author | An, Hyoung Tae | - |
dc.contributor.author | Kim, Jeonghan | - |
dc.contributor.author | Ko, Jesang | - |
dc.date.accessioned | 2021-09-08T10:59:36Z | - |
dc.date.available | 2021-09-08T10:59:36Z | - |
dc.date.created | 2021-06-11 | - |
dc.date.issued | 2009-12 | - |
dc.identifier.issn | 1107-3756 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/118803 | - |
dc.description.abstract | Monocyte chemoattractant protein-1 (MCP-1) is a CC chemokine that plays an important role in immune cell migration. It has been reported that chemokines, including MCP-1, are involved in angiogenesis and metastasis. However, the exact role of chemokines in cancer development is still obscure. We investigated the involvement of MCP-1 in taxol-induced breast cancer cell death. The anti-cancer drug taxol induced MCF-7 breast cancer cell death. Treatment with taxol increased the mRNA expression level of MCP-1 in it dose- and time-dependent manner. Up-regulation of MCP-1 by taxol was augmented in cells treated with rottlerin, a specific inhibitor of protein kinase C delta (PKC delta). In addition, taxol-induced MCP-1 expression was reduced by the ectopic expression of PKC delta in a dose-dependent manner, indicating that PKC delta plays a negative role in taxol-induced MCP-1 expression in MCF-7 cells. On the other hand, taxol-induced up-regulation of MCP-1 was reduced in cells treated with U73122, an inhibitor of phospholipase C (PLC), and ectopic expression of PLC-gamma 1 increased the expression of MCP-1 in taxol-treated MCF-7 cells, indicating that PLC-gamma 1 functions as a positive regulator in taxol-induced MCP-1 expression. These results indicate that MCP-1 is involved in taxol-induced breast cancer cell death and we propose that taxol induces up-regulation of MCP-1 by affecting both positive and negative regulatory signaling pathways. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPANDIDOS PUBL LTD | - |
dc.subject | ATHEROSCLEROTIC LESIONS | - |
dc.subject | MACROPHAGE RECRUITMENT | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | UP-REGULATION | - |
dc.subject | CHEMOKINES | - |
dc.subject | CCL2 | - |
dc.subject | ANGIOGENESIS | - |
dc.subject | CARCINOMA | - |
dc.subject | FAMILY | - |
dc.title | Effects of protein kinase C delta and phospholipase C-gamma 1 on monocyte chemoattractant protein-1 expression in taxol-induced breast cancer cell death | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ko, Jesang | - |
dc.identifier.doi | 10.3892/ijmm_00000303 | - |
dc.identifier.scopusid | 2-s2.0-70350776994 | - |
dc.identifier.wosid | 000271708100019 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, v.24, no.6, pp.853 - 858 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | - |
dc.citation.volume | 24 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 853 | - |
dc.citation.endPage | 858 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | ATHEROSCLEROTIC LESIONS | - |
dc.subject.keywordPlus | MACROPHAGE RECRUITMENT | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | UP-REGULATION | - |
dc.subject.keywordPlus | CHEMOKINES | - |
dc.subject.keywordPlus | CCL2 | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordAuthor | MCP-1 | - |
dc.subject.keywordAuthor | taxol | - |
dc.subject.keywordAuthor | protein kinase C delta | - |
dc.subject.keywordAuthor | phospholipase C | - |
dc.subject.keywordAuthor | signal transduction | - |
dc.subject.keywordAuthor | breast cancer | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.