Association Between Tumor Necrosis Factor alpha 308G/A Polymorphism and Increased Proinflammatory Cytokine Release After Cardiac Surgery With Cardiopulmonary Bypass in the Korean Population
DC Field | Value | Language |
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dc.contributor.author | Yoon, Seung Zhoo | - |
dc.contributor.author | Jang, In-Jin | - |
dc.contributor.author | Choi, Yoon Ji | - |
dc.contributor.author | Kang, Mae Hwa | - |
dc.contributor.author | Lim, Hye Ja | - |
dc.contributor.author | Lim, Young Jin | - |
dc.contributor.author | Lee, Hye Won | - |
dc.contributor.author | Chang, Seong Ho | - |
dc.contributor.author | Yoon, Suk Min | - |
dc.date.accessioned | 2021-09-08T13:07:27Z | - |
dc.date.available | 2021-09-08T13:07:27Z | - |
dc.date.created | 2021-06-11 | - |
dc.date.issued | 2009-10 | - |
dc.identifier.issn | 1053-0770 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/119236 | - |
dc.description.abstract | Objectives: The G-308A polymorphism of the tumor necrosis factor alpha (TNF-alpha) gene has been suggested to be linked to high TNF promoter activity in in vitro studies. However, there have been some controversies in in vivo studies. This study investigated whether A allele at TNF-308 site is associated with (1) the changes in plasma cytokine levels during and after cardiopulmonary bypass (CPB) and (2) an increased incidence of pulmonary morbidity after CPB. Design: Prospective and observational investigation. Setting: A university hospital, single institution. Participants: Patients scheduled for cardiac surgery with CPB. Intervention: TNF genotype was determined by the real-time polymerase chain reaction method. IL-6 and TNF-alpha levels were measured by enzyme-linked immunosorbent assay at the following time points: T1, before initiation of CPB; T2, 30 minutes of CPB; T3, 30 minutes after CPB; T4, 2 hours after CPB; and T5, 24 hours after CPB. The oxygen index, serum creatinine level, 24-hour blood loss, intubation time, and length of intensive care unit (ICU) stay were examined. Measurements and Main Results: The levels of TNF-alpha in group A (TNF-308GA/AA, n = 25) were higher at T3, T4, and T5 than group G (TNF-308GG, n = 225). The levels of IL-6 showed no statistical difference. The oxygenation index, serum creatinine level, 24-hour blood loss, intubation time, and length of ICU stay showed no statistical difference. Conclusions: TNF G-308A polymorphism may be associated with excess TNF-alpha secretion in this study and may not be associated with excess IL-6 secretion and postoperative morbidity after CPB. (C) 2009 Elsevier Inc. All rights reserved | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | W B SAUNDERS CO-ELSEVIER INC | - |
dc.subject | SYSTEMIC INFLAMMATORY RESPONSE | - |
dc.subject | PROMOTER-308 A/G POLYMORPHISM | - |
dc.subject | FACTOR GENE POLYMORPHISM | - |
dc.subject | SEPTIC SHOCK | - |
dc.subject | SUSCEPTIBILITY | - |
dc.subject | METAANALYSIS | - |
dc.subject | FAILURE | - |
dc.title | Association Between Tumor Necrosis Factor alpha 308G/A Polymorphism and Increased Proinflammatory Cytokine Release After Cardiac Surgery With Cardiopulmonary Bypass in the Korean Population | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoon, Seung Zhoo | - |
dc.contributor.affiliatedAuthor | Choi, Yoon Ji | - |
dc.contributor.affiliatedAuthor | Lim, Hye Ja | - |
dc.contributor.affiliatedAuthor | Lee, Hye Won | - |
dc.contributor.affiliatedAuthor | Chang, Seong Ho | - |
dc.identifier.doi | 10.1053/j.jvca.2009.03.004 | - |
dc.identifier.scopusid | 2-s2.0-70349305398 | - |
dc.identifier.wosid | 000270565500010 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, v.23, no.5, pp.646 - 650 | - |
dc.relation.isPartOf | JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA | - |
dc.citation.title | JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA | - |
dc.citation.volume | 23 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 646 | - |
dc.citation.endPage | 650 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Anesthesiology | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Anesthesiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Peripheral Vascular Disease | - |
dc.subject.keywordPlus | SYSTEMIC INFLAMMATORY RESPONSE | - |
dc.subject.keywordPlus | PROMOTER-308 A/G POLYMORPHISM | - |
dc.subject.keywordPlus | FACTOR GENE POLYMORPHISM | - |
dc.subject.keywordPlus | SEPTIC SHOCK | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | FAILURE | - |
dc.subject.keywordAuthor | cardiopulmonary bypass | - |
dc.subject.keywordAuthor | cytokine | - |
dc.subject.keywordAuthor | morbidity | - |
dc.subject.keywordAuthor | polymorphism | - |
dc.subject.keywordAuthor | tumor necrosis factor alpha | - |
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