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LTD induction suppresses LTP-induced hippocampal adult neurogenesis
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Chun, Sung Kun | - |
| dc.contributor.author | Sun, Woong | - |
| dc.contributor.author | Jung, Min Whan | - |
| dc.date.accessioned | 2021-09-08T13:27:26Z | - |
| dc.date.available | 2021-09-08T13:27:26Z | - |
| dc.date.created | 2021-06-11 | - |
| dc.date.issued | 2009-09-23 | - |
| dc.identifier.issn | 0959-4965 | - |
| dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/119301 | - |
| dc.description.abstract | Neurogenesis persists in certain adult brain regions including the dentate gyrus. Recent studies have shown that long-term potentiation (LTP) induction in the afferent pathway enhances adult neurogenesis in the dentate gyrus. Here, we investigated whether long-term depression (LTD) induction also affects adult neurogenesis. We induced LTD in the dentate gyrus in one hemisphere and compared the amount of progenitor proliferation with that in the other hemisphere. Unlike LTP induction, LTD induction per se did not affect progenitor cell proliferation in the dentate gyrus. However, when LTD was induced a day before LTP induction, neuronal progenitor cell proliferation facilitated by LTP induction was markedly blunted. These results show that two forms of synaptic plasticity, LTP and LTD, differentially influence hippocampal adult neurogenesis. NeuroReport 20:1279-1283 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins. | - |
| dc.language | English | - |
| dc.language.iso | en | - |
| dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
| dc.subject | LONG-TERM POTENTIATION | - |
| dc.subject | RAT DENTATE GYRUS | - |
| dc.subject | CELL-PROLIFERATION | - |
| dc.subject | PROGENITOR CELLS | - |
| dc.subject | DEPRESSION | - |
| dc.subject | STRESS | - |
| dc.subject | MECHANISMS | - |
| dc.subject | SYNAPSES | - |
| dc.subject | DEATH | - |
| dc.title | LTD induction suppresses LTP-induced hippocampal adult neurogenesis | - |
| dc.type | Article | - |
| dc.contributor.affiliatedAuthor | Sun, Woong | - |
| dc.identifier.doi | 10.1097/WNR.0b013e3283303794 | - |
| dc.identifier.scopusid | 2-s2.0-70349145437 | - |
| dc.identifier.wosid | 000269808000011 | - |
| dc.identifier.bibliographicCitation | NEUROREPORT, v.20, no.14, pp.1279 - 1283 | - |
| dc.relation.isPartOf | NEUROREPORT | - |
| dc.citation.title | NEUROREPORT | - |
| dc.citation.volume | 20 | - |
| dc.citation.number | 14 | - |
| dc.citation.startPage | 1279 | - |
| dc.citation.endPage | 1283 | - |
| dc.type.rims | ART | - |
| dc.type.docType | Article | - |
| dc.description.journalClass | 1 | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.relation.journalResearchArea | Neurosciences & Neurology | - |
| dc.relation.journalWebOfScienceCategory | Neurosciences | - |
| dc.subject.keywordPlus | LONG-TERM POTENTIATION | - |
| dc.subject.keywordPlus | RAT DENTATE GYRUS | - |
| dc.subject.keywordPlus | CELL-PROLIFERATION | - |
| dc.subject.keywordPlus | PROGENITOR CELLS | - |
| dc.subject.keywordPlus | DEPRESSION | - |
| dc.subject.keywordPlus | STRESS | - |
| dc.subject.keywordPlus | MECHANISMS | - |
| dc.subject.keywordPlus | SYNAPSES | - |
| dc.subject.keywordPlus | DEATH | - |
| dc.subject.keywordAuthor | adult neurogenesis | - |
| dc.subject.keywordAuthor | cell proliferation | - |
| dc.subject.keywordAuthor | hippocampus | - |
| dc.subject.keywordAuthor | LTD and LTP | - |
| dc.subject.keywordAuthor | progenitor | - |
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