Enhanced invasiveness of drug-resistant acute myeloid leukemia cells through increased expression of matrix metalloproteinase-2
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song, Ju Han | - |
dc.contributor.author | Kim, Seung Hyun | - |
dc.contributor.author | Cho, Daeho | - |
dc.contributor.author | Lee, Il-Kwon | - |
dc.contributor.author | Kim, Hyeoung-Joon | - |
dc.contributor.author | Kim, Tae Sung | - |
dc.date.accessioned | 2021-09-08T13:42:10Z | - |
dc.date.available | 2021-09-08T13:42:10Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2009-09-01 | - |
dc.identifier.issn | 0020-7136 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/119336 | - |
dc.description.abstract | The acquired drug resistance as well as extramedullary tissue infiltration of leukemic cells is a major obstacle in leukemia treatment. Excessive egress of leukemia cell blasts results in invasion into various organs or tissues, which is facilitated by the catalytic activities of matrix metalloproteinases (MMPs). However, the migration of chemoresistant leukemia cells remains unclear. Here, we generated drug-resistant variants of the human acute myeloid leukemia cell line (AML-2/WT) by stepwise exposure to anticancer drugs and evaluated the level of MMP-2 in the drug-resistant variants, along with their invasiveness. Each of the drug-resistant cell variants demonstrated predominant increases in the expression and gelatinolytic activity of MMP-2 as well as in invasiveness, which were significantly suppressed by both a MMP-2 Inhibitor and a blocking antibody. Knockdown experiments using MMP-2 short hairpin RNA also indicated that its upregulation was strongly associated with the cells' increased invasive properties. Importantly, elevated levels of MMP-2 activity and invasiveness were observed in ex vivo mononuclear cell of bone marrow from patients with poor responses to chemotherapy. These findings suggest that advanced malignancy due to acquired drug resistance is responsible for the progressive invasiveness of leukemia cells via MMP-2. (C) 2009 UICC | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | IN-VITRO | - |
dc.subject | TUMOR MICROENVIRONMENT | - |
dc.subject | EXTRACELLULAR-MATRIX | - |
dc.subject | CANCER | - |
dc.subject | GROWTH | - |
dc.subject | INHIBITION | - |
dc.subject | METASTASIS | - |
dc.subject | ACTIVATION | - |
dc.subject | INTEGRINS | - |
dc.title | Enhanced invasiveness of drug-resistant acute myeloid leukemia cells through increased expression of matrix metalloproteinase-2 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Tae Sung | - |
dc.identifier.doi | 10.1002/ijc.24386 | - |
dc.identifier.scopusid | 2-s2.0-67650034623 | - |
dc.identifier.wosid | 000268509500010 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CANCER, v.125, no.5, pp.1074 - 1081 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF CANCER | - |
dc.citation.title | INTERNATIONAL JOURNAL OF CANCER | - |
dc.citation.volume | 125 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1074 | - |
dc.citation.endPage | 1081 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | TUMOR MICROENVIRONMENT | - |
dc.subject.keywordPlus | EXTRACELLULAR-MATRIX | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | INTEGRINS | - |
dc.subject.keywordAuthor | drug resistance | - |
dc.subject.keywordAuthor | invasion | - |
dc.subject.keywordAuthor | acute myeloid leukemia | - |
dc.subject.keywordAuthor | matrix metalloproteinase-2 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.