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A bioreactor with an internal contactor for primary recovery of bovine serum albumin from yeast suspension

Authors
Yoon, SejoonSim, HuijunKim, Jun SeokHong, Suk-In
Issue Date
9월-2009
Publisher
KOREAN INSTITUTE CHEMICAL ENGINEERS
Keywords
Protein Recovery; Adsorption; BSA; Internal Contactor; Yeast Suspension
Citation
KOREAN JOURNAL OF CHEMICAL ENGINEERING, v.26, no.5, pp.1323 - 1327
Indexed
SCIE
SCOPUS
KCI
Journal Title
KOREAN JOURNAL OF CHEMICAL ENGINEERING
Volume
26
Number
5
Start Page
1323
End Page
1327
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/119424
DOI
10.1007/s11814-009-0285-5
ISSN
0256-1115
Abstract
In this paper the internal contactor is a newly developed device for the primary recovery of protein from crude feedstock. Ion exchanges (DEAE-Streamline) are confined inside the internal contactor in a stirred tank. Interactions between the ion exchange in the internal contactor and protein (BSA) in yeast suspension have been studied. For better performance, two strategies are considered: to determine the ion conductivity of a simulated yeast suspension, and to select the optimum process time for adsorption. In this system, advantages of both batch adsorption and expanded bed adsorption were obtained. Furthermore, in denser cell concentration (50 g/L) where EBA cannot be operated, the primary recovery was carried out in 1-2 hr. The efficiency of yield is higher than 80% in this condition.
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