In vitro and in vivo antimicrobial activity of water-soluble chitosan oligosaccharides against Vibrio vulnificus
DC Field | Value | Language |
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dc.contributor.author | Lee, Byung Cheol | - |
dc.contributor.author | Kim, Myun Soo | - |
dc.contributor.author | Choi, Sang Ho | - |
dc.contributor.author | Kim, Kwang Yoon | - |
dc.contributor.author | Kim, Tae Sung | - |
dc.date.accessioned | 2021-09-08T14:11:25Z | - |
dc.date.available | 2021-09-08T14:11:25Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2009-09 | - |
dc.identifier.issn | 1107-3756 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/119447 | - |
dc.description.abstract | Vibrio vulnificus is a Gram-negative bacterium that induces severely rapid pathological progress. In this study, we evaluated the antibacterial activity of two water-soluble chitosan oligosaccharides, COS A (MW, 10,000 Da) and COS B (MW, 1,000 Da), from 90-95% deacetylated chitosan, against V. vulnificus in vitro and in vivo. Treatment with COS A resulted in significantly higher suppressive effects on the growth of V. vulnificus than treatment with COS B. The growth of V. vulnificus was inhibited within 1 h of treatment with water-soluble COS A in concentrations ranging from 0.5 to 10 mg/ml. Additionally, treatment with COS A completely inhibited V. vulnificus-induced cytotoxicity in human intestinal epithelial INT-407 cells, while COS B did not. Furthermore, the administration of COS A (0.1-0.5 mg per mouse) significantly increased the survival period of V. vulnificus-infected mice. The number of viable V. vulnificus in the spleen, liver, small intestine, and blood was significantly lower in COS A-treated mice than in untreated mice. Here, we clearly demonstrate that COS A is a potential agent for the prevention and treatment of infection with V. vulnificus. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPANDIDOS PUBL LTD | - |
dc.subject | NECROSIS-FACTOR-ALPHA | - |
dc.subject | MOLECULAR-WEIGHT | - |
dc.subject | CAPSULAR POLYSACCHARIDE | - |
dc.subject | CHITIN | - |
dc.subject | PATHOGENESIS | - |
dc.subject | GROWTH | - |
dc.subject | CELLS | - |
dc.subject | IDENTIFICATION | - |
dc.subject | INFECTION | - |
dc.subject | MIGRATION | - |
dc.title | In vitro and in vivo antimicrobial activity of water-soluble chitosan oligosaccharides against Vibrio vulnificus | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Tae Sung | - |
dc.identifier.doi | 10.3892/ijmm_00000236 | - |
dc.identifier.scopusid | 2-s2.0-70349561461 | - |
dc.identifier.wosid | 000268946500006 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, v.24, no.3, pp.327 - 333 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | - |
dc.citation.volume | 24 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 327 | - |
dc.citation.endPage | 333 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
dc.subject.keywordPlus | MOLECULAR-WEIGHT | - |
dc.subject.keywordPlus | CAPSULAR POLYSACCHARIDE | - |
dc.subject.keywordPlus | CHITIN | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | MIGRATION | - |
dc.subject.keywordAuthor | Vibrio vulnificus | - |
dc.subject.keywordAuthor | chitosan oligosaccharide | - |
dc.subject.keywordAuthor | antimicrobial activity | - |
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