Experimental and Computational Characterization of Biological Liquid Crystals: A Review of Single-Molecule Bioassays
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Eom, Kilho | - |
dc.contributor.author | Yang, Jaemoon | - |
dc.contributor.author | Park, Jinsung | - |
dc.contributor.author | Yoon, Gwonchan | - |
dc.contributor.author | Sohn, Young Soo | - |
dc.contributor.author | Park, Shinsuk | - |
dc.contributor.author | Yoon, Dae Sung | - |
dc.contributor.author | Na, Sungsoo | - |
dc.contributor.author | Kwon, Taeyun | - |
dc.date.accessioned | 2021-09-08T14:16:08Z | - |
dc.date.available | 2021-09-08T14:16:08Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2009-09 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/119461 | - |
dc.description.abstract | Quantitative understanding of the mechanical behavior of biological liquid crystals such as proteins is essential for gaining insight into their biological functions, since some proteins perform notable mechanical functions. Recently, single-molecule experiments have allowed not only the quantitative characterization of the mechanical behavior of proteins such as protein unfolding mechanics, but also the exploration of the free energy landscape for protein folding. In this work, we have reviewed the current state-of-art in single-molecule bioassays that enable quantitative studies on protein unfolding mechanics and/or various molecular interactions. Specifically, single-molecule pulling experiments based on atomic force microscopy (AFM) have been overviewed. In addition, the computational simulations on single-molecule pulling experiments have been reviewed. We have also reviewed the AFM cantilever-based bioassay that provides insight into various molecular interactions. Our review highlights the AFM-based single-molecule bioassay for quantitative characterization of biological liquid crystals such as proteins. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | ATOMIC-FORCE MICROSCOPY | - |
dc.subject | AMPLITUDE CONFORMATIONAL FLUCTUATIONS | - |
dc.subject | COLLECTIVE VARIABLE DESCRIPTION | - |
dc.subject | DYNAMICS SIMULATIONS | - |
dc.subject | UNFOLDING PATHWAYS | - |
dc.subject | ENERGY LANDSCAPE | - |
dc.subject | SECONDARY STRUCTURES | - |
dc.subject | GLOBULAR-PROTEINS | - |
dc.subject | ADHESION BONDS | - |
dc.subject | DNA-MOLECULES | - |
dc.title | Experimental and Computational Characterization of Biological Liquid Crystals: A Review of Single-Molecule Bioassays | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Eom, Kilho | - |
dc.contributor.affiliatedAuthor | Park, Shinsuk | - |
dc.contributor.affiliatedAuthor | Na, Sungsoo | - |
dc.identifier.doi | 10.3390/ijms10094009 | - |
dc.identifier.scopusid | 2-s2.0-70350041087 | - |
dc.identifier.wosid | 000270197800018 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.10, no.9, pp.4009 - 4032 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 10 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 4009 | - |
dc.citation.endPage | 4032 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | ATOMIC-FORCE MICROSCOPY | - |
dc.subject.keywordPlus | AMPLITUDE CONFORMATIONAL FLUCTUATIONS | - |
dc.subject.keywordPlus | COLLECTIVE VARIABLE DESCRIPTION | - |
dc.subject.keywordPlus | DYNAMICS SIMULATIONS | - |
dc.subject.keywordPlus | UNFOLDING PATHWAYS | - |
dc.subject.keywordPlus | ENERGY LANDSCAPE | - |
dc.subject.keywordPlus | SECONDARY STRUCTURES | - |
dc.subject.keywordPlus | GLOBULAR-PROTEINS | - |
dc.subject.keywordPlus | ADHESION BONDS | - |
dc.subject.keywordPlus | DNA-MOLECULES | - |
dc.subject.keywordAuthor | single-molecule experiments | - |
dc.subject.keywordAuthor | atomic force microscope (AFM) | - |
dc.subject.keywordAuthor | coarse-grained molecular dynamics simulation | - |
dc.subject.keywordAuthor | coarse-grained model | - |
dc.subject.keywordAuthor | in vitro molecular recognitions | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.