IL-10 Suppresses Calcium-Mediated Costimulation of Receptor Activator NF-kappa B Signaling during Human Osteoclast Differentiation by Inhibiting TREM-2 Expression
DC Field | Value | Language |
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dc.contributor.author | Park-Min, Kyung-Hyun | - |
dc.contributor.author | Ji, Jong-Dae | - |
dc.contributor.author | Antoniv, Taras | - |
dc.contributor.author | Reid, Alicia C. | - |
dc.contributor.author | Silver, Randi B. | - |
dc.contributor.author | Humphrey, Mary Beth | - |
dc.contributor.author | Nakamura, Mary | - |
dc.contributor.author | Ivashkiv, Lionel B. | - |
dc.date.accessioned | 2021-09-08T14:40:38Z | - |
dc.date.available | 2021-09-08T14:40:38Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2009-08-15 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/119486 | - |
dc.description.abstract | Induction of effective osteoclastogenesis by RANK (receptor activator of NF-kappa B) requires costimulation by ITAM-coupled receptors. In humans, the TREM-2 (triggering receptor expressed on myeloid cells 2) ITAM-coupled receptor plays a key role in bone remodeling, as patients with TREM-2 mutations exhibit defective osteoclastogenesis and bone lesions. We have identified a new rapidly induced costimulatory pathway for RANK signaling that is dependent on TREM-2 and mediated by calcium signaling. TREM-2-dependent calcium signals are required for RANK-mediated activation of calcium/calmodulin-dependent protein kinase (CaMK)II and downstream MEK and ERK MAPKs that are important for osteoclastogenesis. IL-10 inhibited RANK-induced osteoclastogenesis and selectively inhibited calcium signaling downstream of RANK by inhibiting transcription of TREM-2. Down-regulation of TREM-2 expression resulted in diminished RANKL-induced activation of the CaMK-MEK-ERK pathway and decreased expression of the master regulator of osteoclastogenesis NFATc1. These findings provide a new mechanism of inhibition of human osteoclast differentiation. The results also yield insights into crosstalk between ITAM-coupled receptors and heterologous receptors such as RANK, and they identify a mechanism by which IL-10 can suppress cellular responses to TNFR family members. The Journal of Immunology, 2009, 183: 2444-2455. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER ASSOC IMMUNOLOGISTS | - |
dc.subject | ALVEOLAR BONE LOSS | - |
dc.subject | CUTTING EDGE | - |
dc.subject | ADAPTER PROTEINS | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | IN-VIVO | - |
dc.subject | C-FOS | - |
dc.subject | INTERLEUKIN-10 | - |
dc.subject | RANKL | - |
dc.subject | TRANSCRIPTION | - |
dc.subject | CELLS | - |
dc.title | IL-10 Suppresses Calcium-Mediated Costimulation of Receptor Activator NF-kappa B Signaling during Human Osteoclast Differentiation by Inhibiting TREM-2 Expression | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ji, Jong-Dae | - |
dc.identifier.doi | 10.4049/jimmunol.0804165 | - |
dc.identifier.scopusid | 2-s2.0-70149090443 | - |
dc.identifier.wosid | 000268906500031 | - |
dc.identifier.bibliographicCitation | JOURNAL OF IMMUNOLOGY, v.183, no.4, pp.2444 - 2455 | - |
dc.relation.isPartOf | JOURNAL OF IMMUNOLOGY | - |
dc.citation.title | JOURNAL OF IMMUNOLOGY | - |
dc.citation.volume | 183 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 2444 | - |
dc.citation.endPage | 2455 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | ALVEOLAR BONE LOSS | - |
dc.subject.keywordPlus | CUTTING EDGE | - |
dc.subject.keywordPlus | ADAPTER PROTEINS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | C-FOS | - |
dc.subject.keywordPlus | INTERLEUKIN-10 | - |
dc.subject.keywordPlus | RANKL | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | ALVEOLAR BONE LOSS | - |
dc.subject.keywordAuthor | CUTTING EDGE | - |
dc.subject.keywordAuthor | ADAPTER PROTEINS | - |
dc.subject.keywordAuthor | GENE-EXPRESSION | - |
dc.subject.keywordAuthor | IN-VIVO | - |
dc.subject.keywordAuthor | C-FOS | - |
dc.subject.keywordAuthor | INTERLEUKIN-10 | - |
dc.subject.keywordAuthor | RANKL | - |
dc.subject.keywordAuthor | TRANSCRIPTION | - |
dc.subject.keywordAuthor | CELLS | - |
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