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Membrane-Delimited Coupling of TRPV1 and mGluR5 on Presynaptic Terminals of Nociceptive Neurons

Authors
Kim, Yong HoPark, Chul-KyuBack, Seung KeunLee, C. JustinHwang, Se JinBae, Yong ChulNa, Heung SikKim, Joong SooJung, Sung JunOh, Seog Bae
Issue Date
12-8월-2009
Publisher
SOC NEUROSCIENCE
Keywords
METABOTROPIC GLUTAMATE RECEPTORS; RAT SPINAL-CORD; VANILLOID RECEPTOR; DORSAL-HORN; CAPSAICIN RECEPTOR; SYNAPTIC-TRANSMISSION; SUBSTANTIA-GELATINOSA; SUPERFICIAL LAMINAE; POTENTIAL CHANNELS; DIRECT ACTIVATION
Citation
JOURNAL OF NEUROSCIENCE, v.29, no.32, pp.10000 - 10009
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF NEUROSCIENCE
Volume
29
Number
32
Start Page
10000
End Page
10009
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/119495
DOI
10.1523/JNEUROSCI.5030-08.2009
ISSN
0270-6474
Abstract
Transient receptor potential vanilloid subtype 1 (TRPV1) and metabotropic glutamate receptor 5 (mGluR5) located on peripheral sensory terminals have been shown to play critical roles in the transduction and modulation of pain sensation. To date, however, very little is known regarding the significance of functional expression of mGluR5 and TRPV1 on the central terminals of sensory neurons in the dorsal horn of the spinal cord. Here we show that TRPV1 on central presynaptic terminals is coupled to mGluR5 in a membrane-delimited manner, thereby contributing to the modulation of nociceptive synaptic transmission in the substantia gelatinosa neurons of the spinal cord. Further, our results demonstrate that TRPV1 is involved in the pain behaviors induced by spinal mGluR5 activation, and diacylglycerol produced by the activation of mGluR5 mediates functional coupling of mGluR5 and TRPV1 on the presynaptic terminals. Thus, mGluR5-TRPV1 coupling on the central presynaptic terminals of nociceptive neurons may be an important mechanism underlying central sensitization under pathological pain conditions.
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