Depth of tumor invasion better predicts prognosis than the current American Joint Committee on Cancer T classification for distal bile duct carcinoma
DC Field | Value | Language |
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dc.contributor.author | Hong, Seung-Mo | - |
dc.contributor.author | Pawlik, Timothy M. | - |
dc.contributor.author | Cho, HyungJun | - |
dc.contributor.author | Aggarwal, Bhuvnesh | - |
dc.contributor.author | Goggins, Michael | - |
dc.contributor.author | Hruban, Ralph H. | - |
dc.contributor.author | Anders, Robert A. | - |
dc.date.accessioned | 2021-09-08T15:03:20Z | - |
dc.date.available | 2021-09-08T15:03:20Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2009-08 | - |
dc.identifier.issn | 0039-6060 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/119545 | - |
dc.description.abstract | Background. The American joint Committee on Cancer (AJCC) T classification system for cholangiocarcinoma does not take into account the unique pathologic features of the bile duct. As such, the current AJCC T classification for distal cholangiocarcinoma may be inaccurate. Methods. A total of 14 7 patients with distal cholangiocarcinoma were identified from a single institution database. The prognostic importance of depth of tumor invasion relative to the AJCC T classification system was assessed. Results. The A C T classification was T1 (n = 11, 7.5%), T2 (n = 0, 4.1%), T3 (n = 73, 49.7%), or T4 (n = 5 7, 38.8%). When cases were analyzed according to depth of tumor invasion, most lesions were >= 5 mm (<5 mm, 9.5%; range, 5-12, 5 1.0%; >12 mm, 39.5%). The AJCC T classification was not associated with survival outcome (median survival, T1, 40.1 months; T2, 14.8 months; T3, 16.5 months; 74, 20.2 months; P = .17). In contrast, depth of tumor invasion was associated with a worse outcome as tumor depth increased (median survival, <5 mm, not reached; range, 5-12, 28.9 months; >12 mm, 12.9 months; P =. 001). On multivariate analyses, tumor depth remained the factor most associated with outcome (<.5 mm; hazard ratio [HR] = referent vs 5-12 mm; HR = 3.8 vs >12 mm; HR = 6.7 mm; P =. 001). Conclusion. The AJCC T classification for distal cholangiocarcinoma does not accurately predict prognosis. Depth of the bile duct carcinoma invasion is a better alternative method to determine prognosis and should be incorporated into the pathologic assessment of resected distal cholangiocarcinoma. (Surgery 2009,146:250-7.) | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MOSBY-ELSEVIER | - |
dc.subject | SEER DATABASE ANALYSIS | - |
dc.subject | LIVER RESECTION | - |
dc.subject | STAGING SYSTEM | - |
dc.subject | CHOLANGIOCARCINOMA | - |
dc.subject | FEATURES | - |
dc.subject | PANCREATICODUODENECTOMY | - |
dc.subject | SURVIVAL | - |
dc.subject | NEOPLASM | - |
dc.subject | SURGERY | - |
dc.subject | TRENDS | - |
dc.title | Depth of tumor invasion better predicts prognosis than the current American Joint Committee on Cancer T classification for distal bile duct carcinoma | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Cho, HyungJun | - |
dc.identifier.doi | 10.1016/j.surg.2009.02.023 | - |
dc.identifier.scopusid | 2-s2.0-67650566650 | - |
dc.identifier.wosid | 000268972200016 | - |
dc.identifier.bibliographicCitation | SURGERY, v.146, no.2, pp.250 - 257 | - |
dc.relation.isPartOf | SURGERY | - |
dc.citation.title | SURGERY | - |
dc.citation.volume | 146 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 250 | - |
dc.citation.endPage | 257 | - |
dc.type.rims | ART | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | SEER DATABASE ANALYSIS | - |
dc.subject.keywordPlus | LIVER RESECTION | - |
dc.subject.keywordPlus | STAGING SYSTEM | - |
dc.subject.keywordPlus | CHOLANGIOCARCINOMA | - |
dc.subject.keywordPlus | FEATURES | - |
dc.subject.keywordPlus | PANCREATICODUODENECTOMY | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | NEOPLASM | - |
dc.subject.keywordPlus | SURGERY | - |
dc.subject.keywordPlus | TRENDS | - |
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