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Comparison of the Novel Human Papillomavirus 4 Auto-capillary Electrophoresis Test with the Hybrid Capture 2 Assay and with the PCR HPV Typing Set Test in the Detection of High-Risk HPV Including HPV 16 and 18 Genotypes in Cervical Specimens

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dc.contributor.authorHong, Jin Hwa-
dc.contributor.authorSong, Seung Hun-
dc.contributor.authorKim, Jong Kee-
dc.contributor.authorHan, Jeong Hyun-
dc.contributor.authorLee, Jae Kwan-
dc.date.accessioned2021-09-08T15:13:10Z-
dc.date.available2021-09-08T15:13:10Z-
dc.date.created2021-06-10-
dc.date.issued2009-08-
dc.identifier.issn1011-8934-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/119591-
dc.description.abstractThe aim of this study was to compare the novel human papillomavirus (HPV) detection method, the HPV 4 Auto-capillary Electrophoresis (ACE) test with the hybrid capture (HC) 2 assay for the detection of high-risk HPVs. In addition, we compared the HPV 4 ACE test with the polymerase chain reaction HPV Typing Set test for the detection of HPV 16 and HPV 18 genotypes. One hundred ninety-nine cervical swab samples obtained from women with previous abnormal Pap smears were subjected to testing with the three HPV tests. The HPV 4 ACE test and the HC 2 assay showed substantial agreement for detection of high-risk HPVs (85.4%, kappa=0.71). The HPV 4 ACE test also showed substantial agreement with the PCR HPV Typing Set test in the detection of HPV 16 and HP V 18 genotypes (89.9%, kappa=0.65). In correlation with cytologic results, the sensitivities and specificities of the HPV 4 ACE test and HC 2 assay were 92.9% vs. 92.9% and 48.1% vs. 50.8%, respectively, when high-grade squamous intraepithelial lesions were regarded as abnormal cytologies. The novel HPV 4 ACE test is a valuable tool for the detection of high-risk HPVs and for genotyping of HPV 16 and HPV 18.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherKOREAN ACAD MEDICAL SCIENCES-
dc.subjectMULTIPLEX DETECTION-
dc.subjectROCHE AMPLICOR-
dc.subjectWOMEN-
dc.subjectCANCER-
dc.subjectDNA-
dc.subjectINFECTIONS-
dc.subjectPREVALENCE-
dc.subjectPRIMERS-
dc.titleComparison of the Novel Human Papillomavirus 4 Auto-capillary Electrophoresis Test with the Hybrid Capture 2 Assay and with the PCR HPV Typing Set Test in the Detection of High-Risk HPV Including HPV 16 and 18 Genotypes in Cervical Specimens-
dc.typeArticle-
dc.contributor.affiliatedAuthorHong, Jin Hwa-
dc.contributor.affiliatedAuthorSong, Seung Hun-
dc.contributor.affiliatedAuthorLee, Jae Kwan-
dc.identifier.doi10.3346/jkms.2009.24.4.579-
dc.identifier.scopusid2-s2.0-70350743159-
dc.identifier.wosid000268940300006-
dc.identifier.bibliographicCitationJOURNAL OF KOREAN MEDICAL SCIENCE, v.24, no.4, pp.579 - 584-
dc.relation.isPartOfJOURNAL OF KOREAN MEDICAL SCIENCE-
dc.citation.titleJOURNAL OF KOREAN MEDICAL SCIENCE-
dc.citation.volume24-
dc.citation.number4-
dc.citation.startPage579-
dc.citation.endPage584-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.identifier.kciidART001366230-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.relation.journalResearchAreaGeneral & Internal Medicine-
dc.relation.journalWebOfScienceCategoryMedicine, General & Internal-
dc.subject.keywordPlusMULTIPLEX DETECTION-
dc.subject.keywordPlusROCHE AMPLICOR-
dc.subject.keywordPlusWOMEN-
dc.subject.keywordPlusCANCER-
dc.subject.keywordPlusDNA-
dc.subject.keywordPlusINFECTIONS-
dc.subject.keywordPlusPREVALENCE-
dc.subject.keywordPlusPRIMERS-
dc.subject.keywordAuthorHPV Typing Methods-
dc.subject.keywordAuthorACE-
dc.subject.keywordAuthorHC2-
dc.subject.keywordAuthorHPV Typing Set Test-
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