Comparison of the Novel Human Papillomavirus 4 Auto-capillary Electrophoresis Test with the Hybrid Capture 2 Assay and with the PCR HPV Typing Set Test in the Detection of High-Risk HPV Including HPV 16 and 18 Genotypes in Cervical Specimens
DC Field | Value | Language |
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dc.contributor.author | Hong, Jin Hwa | - |
dc.contributor.author | Song, Seung Hun | - |
dc.contributor.author | Kim, Jong Kee | - |
dc.contributor.author | Han, Jeong Hyun | - |
dc.contributor.author | Lee, Jae Kwan | - |
dc.date.accessioned | 2021-09-08T15:13:10Z | - |
dc.date.available | 2021-09-08T15:13:10Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2009-08 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/119591 | - |
dc.description.abstract | The aim of this study was to compare the novel human papillomavirus (HPV) detection method, the HPV 4 Auto-capillary Electrophoresis (ACE) test with the hybrid capture (HC) 2 assay for the detection of high-risk HPVs. In addition, we compared the HPV 4 ACE test with the polymerase chain reaction HPV Typing Set test for the detection of HPV 16 and HPV 18 genotypes. One hundred ninety-nine cervical swab samples obtained from women with previous abnormal Pap smears were subjected to testing with the three HPV tests. The HPV 4 ACE test and the HC 2 assay showed substantial agreement for detection of high-risk HPVs (85.4%, kappa=0.71). The HPV 4 ACE test also showed substantial agreement with the PCR HPV Typing Set test in the detection of HPV 16 and HP V 18 genotypes (89.9%, kappa=0.65). In correlation with cytologic results, the sensitivities and specificities of the HPV 4 ACE test and HC 2 assay were 92.9% vs. 92.9% and 48.1% vs. 50.8%, respectively, when high-grade squamous intraepithelial lesions were regarded as abnormal cytologies. The novel HPV 4 ACE test is a valuable tool for the detection of high-risk HPVs and for genotyping of HPV 16 and HPV 18. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | - |
dc.subject | MULTIPLEX DETECTION | - |
dc.subject | ROCHE AMPLICOR | - |
dc.subject | WOMEN | - |
dc.subject | CANCER | - |
dc.subject | DNA | - |
dc.subject | INFECTIONS | - |
dc.subject | PREVALENCE | - |
dc.subject | PRIMERS | - |
dc.title | Comparison of the Novel Human Papillomavirus 4 Auto-capillary Electrophoresis Test with the Hybrid Capture 2 Assay and with the PCR HPV Typing Set Test in the Detection of High-Risk HPV Including HPV 16 and 18 Genotypes in Cervical Specimens | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hong, Jin Hwa | - |
dc.contributor.affiliatedAuthor | Song, Seung Hun | - |
dc.contributor.affiliatedAuthor | Lee, Jae Kwan | - |
dc.identifier.doi | 10.3346/jkms.2009.24.4.579 | - |
dc.identifier.scopusid | 2-s2.0-70350743159 | - |
dc.identifier.wosid | 000268940300006 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, v.24, no.4, pp.579 - 584 | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.title | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.volume | 24 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 579 | - |
dc.citation.endPage | 584 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001366230 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | MULTIPLEX DETECTION | - |
dc.subject.keywordPlus | ROCHE AMPLICOR | - |
dc.subject.keywordPlus | WOMEN | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordPlus | INFECTIONS | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | PRIMERS | - |
dc.subject.keywordAuthor | HPV Typing Methods | - |
dc.subject.keywordAuthor | ACE | - |
dc.subject.keywordAuthor | HC2 | - |
dc.subject.keywordAuthor | HPV Typing Set Test | - |
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