Suppression of Th2-driven, allergen-induced airway inflammation by sauchinone
DC Field | Value | Language |
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dc.contributor.author | Min, Hyun Jung | - |
dc.contributor.author | Won, Hee Yeon | - |
dc.contributor.author | Kim, Young Choong | - |
dc.contributor.author | Sung, Sang Hyun | - |
dc.contributor.author | Byun, Mi Ran | - |
dc.contributor.author | Hwang, Jun-Ha | - |
dc.contributor.author | Hong, Jeong-Ho | - |
dc.contributor.author | Hwang, Eun Sook | - |
dc.date.accessioned | 2021-09-08T15:26:52Z | - |
dc.date.available | 2021-09-08T15:26:52Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2009-07-24 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/119654 | - |
dc.description.abstract | Sauchinone, a lignan compound isolated from the root of saururus chinensis, has been recently demonstrated to exhibit anti-inflammatory, activity via the Suppression of NF-kB p65 activity in vitro. In an effort to evaluate the in vivo anti-inflammatory function of sauchinone, we have evaluated the effects of sauchinone on allergen-induced airway inflammation using a murine model of allergic asthma. We observed that marked eosinophilic and lymphocyte infiltration in the BAL fluid were suppressed to a significant degree by sauchinone, and that mucus-secreting goblet cell hyperplasia and collagen deposition in the airways were also ameliorated by administration of sauchinone treatment. Moreover, gene expression of the inflammatory cytokines, IL-13, and IL-5 and eotaxin in the lung, and IL-5 in the draining lymph node were significantly decreased in sauchinone-treated mice. We demonstrated that sauchinone repressed Th2 cell development in vitro and IL-4 production by Th2 cells, and also inhibited GATA-3-mediated IL-5 promoter activity in a close-dependent manner. Collectively, sauchinone ameliorated allergen-induced airway inflammation, in part, by repressing GATA-3 activity for Th2 cell development, indicating the possible therapeutic potential of sauchinone in airway inflammatory diseases including allergic asthma and rhinitis. (C) 2009 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | SAURURUS-CHINENSIS | - |
dc.subject | EOSINOPHIL RECRUITMENT | - |
dc.subject | EXPRESSION | - |
dc.subject | ASTHMA | - |
dc.subject | LUNG | - |
dc.subject | INHIBITION | - |
dc.subject | LIGNAN | - |
dc.subject | GATA-3 | - |
dc.subject | IL-13 | - |
dc.subject | INTERLEUKIN-5 | - |
dc.title | Suppression of Th2-driven, allergen-induced airway inflammation by sauchinone | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hong, Jeong-Ho | - |
dc.identifier.doi | 10.1016/j.bbrc.2009.05.039 | - |
dc.identifier.scopusid | 2-s2.0-67349252050 | - |
dc.identifier.wosid | 000267037300015 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.385, no.2, pp.204 - 209 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 385 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 204 | - |
dc.citation.endPage | 209 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | SAURURUS-CHINENSIS | - |
dc.subject.keywordPlus | EOSINOPHIL RECRUITMENT | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | ASTHMA | - |
dc.subject.keywordPlus | LUNG | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | LIGNAN | - |
dc.subject.keywordPlus | GATA-3 | - |
dc.subject.keywordPlus | IL-13 | - |
dc.subject.keywordPlus | INTERLEUKIN-5 | - |
dc.subject.keywordAuthor | Sauchinone | - |
dc.subject.keywordAuthor | Allergen-induced airway inflammation | - |
dc.subject.keywordAuthor | GATA-3 | - |
dc.subject.keywordAuthor | Th2 cell development | - |
dc.subject.keywordAuthor | Airway inflammatory diseases | - |
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